Korean J Gastroenterol.  2015 Jun;65(6):366-369. 10.4166/kjg.2015.65.6.366.

A Case of Disseminated Intra-abdominal Gastrointestinal Stromal Tumor Managed with Low Dose Imatinib

Affiliations
  • 1Division of Gastroenterology, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea. gastro@catholic.ac.kr

Abstract

Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. Imatinib mesylate is recommended as adjuvant therapy for GIST after surgical resection. However, drug-related adverse events are common. A 74-year-old female with metastatic GIST who was managed with imatinib experienced severe adverse events, including skin rashes, tremor, and alopecia, etc. The imatinib dose was reduced and the size of the metastatic GIST continued to decrease and adverse events showed significant improvement.

Keyword

Gastrointestinal stromal tumors; Imatinib

MeSH Terms

Aged
Antineoplastic Agents/adverse effects/*therapeutic use
Exanthema/etiology
Female
Gastrointestinal Neoplasms/diagnosis/*drug therapy/pathology
Gastrointestinal Stromal Tumors/diagnosis/*drug therapy/pathology
Humans
Imatinib Mesylate/adverse effects/*therapeutic use
Immunohistochemistry
Proto-Oncogene Proteins c-kit/metabolism
Tomography, X-Ray Computed
Antineoplastic Agents
Imatinib Mesylate
Proto-Oncogene Proteins c-kit

Figure

  • Fig. 1. CT scan of the abdomen shows multiple lobulated solid masses with central necrosis in the gastrosplenic space and in both paracolic gutters (arrows).

  • Fig. 2. (A) Photomicrograph of the biopsy specimen (H&E stain, ×200) shows spindle cells on the entire field. (B) Immunohistochemical staining for c-kit (×100) shows diffuse positivity on the entire field.

  • Fig. 3. Photograph of the patient's fore-arm skin shows multiple rashes on the whole fore-arm.

  • Fig. 4. (A) CT scan of the abdomen 3 months after imatinib mesylate administration shows decrease in size of the lesions (arrows). (B) CT scan of the abdomen 9 months after imatinib mesylate administration shows further decrease in size of the lesions (arrows).


Reference

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