J Korean Ophthalmol Soc.  2017 Mar;58(3):276-282. 10.3341/jkos.2017.58.3.276.

Comparison of Central Corneal Thickness Measured by Swept-source Optical Coherence Tomography and Ultrasound Pachymetry

• Shin WB
• Jeong HK
• Kim MK
• Kim HS
• Lee JM
• Kim CY
• Kim JH

• KMID: 2371907
• DOI: http://doi.org/10.3341/jkos.2017.58.3.276

Abstract

PURPOSE
To analyze and compare ultrasound pachymetry (USP) with a more recently adopted device, the intra ocular lens (IOL) master 700, which are both used to measure central corneal thickness.
METHODS
The central corneal thickness was measured in 24 eyes of 12 glaucoma patients and in 83 eyes of 42 normal patients. First, the IOL master 700 was used to measure the central corneal thickness, followed by measurements taken using USP later. The results were analyzed using a paired t-test. We analyzed the agreement and the correlations between the two test devices by using Bland-Altman plots and the Pearson correlation test. To evaluate the reproducibility, measurements with the IOL master 700 were taken twice for a few normal patients within a small time interval.
RESULTS
Via the IOL master 700, the thickness of the central cornea showed a high reproducibility and repeatability, demonstrating 2.7 ± 1.7 µm for the test-retest variability, 6.78% for the coefficient of variation, and 0.997 for the intraclass correlation value. The mean measurements using USP and the IOL master 700 are 554.4 ± 37.4 µm and 551.1 ± 37.1 µm, respectively, showing that the IOL master 700 measured significantly smaller values than USP with a p-value < 0.001. The deviations between the two methods are scattered throughout the 95% confidence interval. According to the Pearson correlation test, the measured values of the two test devices were found to have a highly positive correlation (r = 0.977, p < 0.0001).
CONCLUSIONS
This study demonstrated that the central corneal thickness (CCT) measured via the IOL master was significantly thinner than that of USP, and the two test devices had a high correlation and good agreement. The CCT value measured via the IOL master 700 also exhibited high reproducibility.

Keyword

Central corneal thickness; Ultrasound pachymetry; IOL master 700

MeSH Terms

Cornea
Glaucoma
Humans
Tomography, Optical Coherence*
Ultrasonography*

Figure

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  Figure 1 Bland Altman plots between the 2 methods. The middleline is the mean and the lines on the side represent the upper and lower 95% limits of agreement. USP = ultrasound pachymetry; IOL = intraocular lens; SD = standard deviation.

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  Figure 2 Correlation analysis graph (Scatter plot) between the 2 methods. Scattergram showing the correlation of central corneal thickness measured by USP and IOL master 700. USP = ultrasound pachymetry; IOL = intraocular lens.

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