Korean J Vet Res.  2016 Mar;56(1):47-49. 10.14405/kjvr.2016.56.1.47.

Combination therapy of cyclosporine and prednisolone in a dog with systemic lupus erythematosus

• Kim YH
• Kang MH
• Park HM

• KMID: 2368742
• DOI: http://doi.org/10.14405/kjvr.2016.56.1.47

Abstract

An 11-year-old, spayed female poodle presented with fever and shifting lameness. Physical examination revealed hyperthermia (40.6℃), and proteinuria was detected upon urinalysis. Increased neutrophils (83%) and decreased viscosity were revealed upon synovial fluid analysis. Serum antinuclear antibody was positive at 1 : 80. Based on these findings, the dog was diagnosed with systemic lupus erythematosus. Immunosuppressive therapy was initiated with prednisolone and cyclosporine, and the condition was markedly improved after the treatments. This case report describes the clinical and laboratory findings, imaging characteristics and successful outcomes after prednisolone plus cyclosporine therapy in a canine systemic lupus erythematosus case.

Keyword

antinuclear antibody; cyclosporine; glomerulonephritis; polyarthritis; systemic lupus erythematosus

MeSH Terms

Animals
Antibodies, Antinuclear
Arthritis
Child
Cyclosporine*
Dogs*
Female
Fever
Glomerulonephritis
Humans
Lupus Erythematosus, Systemic*
Neutrophils
Physical Examination
Prednisolone*
Proteinuria
Synovial Fluid
Urinalysis
Viscosity
Antibodies, Antinuclear
Cyclosporine
Prednisolone