Korean J Vet Res.  2021 Mar;61(1):e1. 10.14405/kjvr.2021.61.e1.

Successful management of systemic lupus erythematosus with levamisole in a Dachshund dog

Affiliations
  • 1Department of Veterinary Internal Medicine, Konkuk University Veterinary Medical Teaching Hospital, Seoul 05029, Korea
  • 2Department of Veterinary Emergency, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea
  • 3Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea

Abstract

A 5-year-old neutered female Dachshund dog presented with a 3-month history of hyperthermia, skin lesions, and shifting lameness. Based on physical examination, blood tests, urinalysis, and radiographs, the dog was diagnosed with systemic lupus erythematosus. Clinical signs improved after administration of prednisolone and cyclosporine but relapsed after the prednisolone was reduced due to side effects. Oral levamisole was commenced and the other immunosuppressants were tapered over a period of 2 months and then stopped. Levamisole was retained as the sole therapy for an additional 2 months. Six months after discontinuation of all treatment, the patient remained in remission.

Keyword

autoimmune disease; levamisole; regulatory T-cells; systemic lupus erythematosus
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