Korean J Vet Res.
2016 Mar;56(1):23-28. 10.14405/kjvr.2016.56.1.23.
Genetic diversity of nucleocapsid genes of recent porcine epidemic diarrhea viruses isolated in Korea
- Affiliations
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- 1College of Veterinary Medicine & Institute of Veterinary Science, Kangwon National University, Chuncheon 24341, Korea. twhahn@kangwon.ac.kr
- 2College of Veterinary Medicine, Jeju National University, Jeju 63241, Korea.
- KMID: 2368737
- DOI: http://doi.org/10.14405/kjvr.2016.56.1.23
Abstract
- Porcine epidemic diarrhea virus (PEDV), a porcine enteropathogenic coronavirus, causes lethal watery diarrhea in piglets, resulting in large economic losses because of high mortality. In November 2013, PEDV reemerged in Korea, and these outbreaks have since continuously occurred. In the present study, we determined the full-length nucleocapsid (N) gene sequences of three Korean PEDV field isolates collected in 2014-2015. Sequence and phylogenetic analysis of N genes revealed that recent prevalent Korean PEDV isolates were very closely related to the US PEDV isolates in 2013. Interestingly, the phylogenetic tree based on the nucleotide sequencing of the PEDV N gene was similar to the tree topology of the PEDV complete genomes. Therefore, our data provide a better understanding of the genetic diversity and contribute to the accurate diagnosis and development of vaccines against PEDV.
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