Korean J Parasitol.  2016 Dec;54(6):719-724. 10.3347/kjp.2016.54.6.719.

Dynamic Patterns of Systemic Innate Immunity and Inflammatory Associated Factors in Experimental Caprine Coccidiosis

• Tadayon S
• Razavi SM
• Nazifi S

• KMID: 2367412
• DOI: http://doi.org/10.3347/kjp.2016.54.6.719

Abstract

The present study was designed to assess the dynamic patterns of pro-inflammatory cytokines, including IFN-γ, TNF-α, IL-4, IL-6, acute phase protein (α1-acid-glycoprotein, AGP), and an inflammation associated factor (adenosine deaminase; ADA) following experimental caprine coccidiosis. Ten kids aging from 2 to 4 months were infected orally with 5×104 sporulated oocysts and 10 animals served as controls. Blood samples were collected in both groups before infection and at days 3, 7, 14, 21, 28, and 35 post-infection (PI), and the levels of above-mentioned factors were measured. IFN-γ, TNF-α, IL-4, IL-6, AGP, and ADA activities were significantly higher in infected animals from day 7 PI (P<0.05). In conclusion, the circulatory levels of most systemic inflammatory markers, including pro-inflammatory cytokines (IFN-γ, TNF-α, IL-4, IL-6), AGP, and ADA increased significantly starting from day 3 to day 7 PI in caprine coccidiosis.

Keyword

Eimeria caprina; Eimeria ninakohlyakimovae; Eimeria arloingi; systemic innate immunity; inflammatory factor; caprine coccidiosis

MeSH Terms

Acute-Phase Proteins
Aging
Animals
Coccidiosis*
Cytokines
Immunity, Innate*
Inflammation
Interleukin-4
Interleukin-6
Oocysts
Acute-Phase Proteins
Cytokines
Interleukin-4
Interleukin-6