Child Kidney Dis.
2016 Oct;20(2):45-49. 10.3339/jkspn.2016.20.2.45.
The Cyclosporine-A Treatment does not have Harmful Effect on the Linear Growth of Pediatric Patients with Steroid-dependent and Steroid-resistant Nephrotic Syndrome
- Affiliations
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- 1Department of Pediatrics, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. rebekahjs@hanmail.net
- 2Department of Nuclear Medicine, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- 3Director of MIRAE-iNG Kidney Center, Seoul, Korea.
- 4Department of Nuclear Medicine, School of Medicine, Kyung Hee University, Seoul, Korea.
- KMID: 2366595
- DOI: http://doi.org/10.3339/jkspn.2016.20.2.45
Abstract
- PURPOSE
This study was performed to evaluate the effects of cyclosporine-A (CsA) on linear growth in pediatric patients with steroid-dependent (SDNS) or resistant nephrotic syndrome (SRNS).
METHODS
Thirty-five pediatric patients with SDNS or SRNS undergoing glucocorticoid (GC) and/or CsA treatment were retrospectively reviewed. Seventeen patients were treated with GC alone and 18 were treated with GC and CsA. The cumulative doses of GC and CsA were quantified (mg/kg/day). Linear growth during the follow-up period was defined as the difference in Z-score between the initial and final height according to the follow-up period (Δ height Z score/year). The associations between linear growth and clinical parameters were analyzed.
RESULTS
The linear growth of patients in the two groups was not significantly different (P=0.262). The Δ height Z score/year did not show a significant correlation with the cumulative doses of CsA, but was negatively correlated with the cumulative dose of GC and positively correlated with the Z score for height at the time of diagnosis.
CONCLUSION
In children with SDNS or SRNS undergoing GC therapy, added CsA treatment may not have harmful effects on linear growth.
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