Int Neurourol J.
2016 Dec;20(4):321-328. 10.5213/inj.1632584.292.
Obesity as a Risk Factor for Prostatic Enlargement: A Retrospective Cohort Study in Korea
- Affiliations
-
- 1Department of Urology, Yonsei University Wonju College of Medicine, Wonju, Korea.
- 2Department of Preventive Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea. kohhj@yonsei.ac.kr
- 3Institute of Genomic Cohort, Yonsei University Wonju College of Medicine, Wonju, Korea.
- 4Department of Urology, CHA Gangnam Medical Center, CHA University, Seoul, Korea.
- 5Department of Otolaryngology, Head and Neck Surgery, Yonsei University Wonju College of Medicine, Wonju, Korea.
- 6Institute of Occupational and Environmental Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
- KMID: 2365697
- DOI: http://doi.org/10.5213/inj.1632584.292
Abstract
- PURPOSE
We aimed to evaluate obesity, a risk factor of metabolic syndrome, and its association with prostatic enlargement in a retrospective cohort in Korea.
METHODS
Baseline data were obtained from the Korean Genome and Epidemiology Study on Atherosclerosis Risk of Rural Areas in the Korean General Population (KoGES-ARIRANG). Between March 2015 and November 2015, 2,127 male participants of KoGES-ARIRANG were invited to the Korean Prostate Health Council Screening Program, and 602 participants underwent urological examination, including serum prostate specific antigen measurement and transrectal ultrasonography, and completed the International Prostate Symptom Score questionnaire. The data for 571 participants were analyzed, after excluding 31 men who had a history of prostatic disease or testosterone replacement, or had undergone a prior prostatic surgery or procedure.
RESULTS
Among components of metabolic syndrome, waist circumference had a statistically significant linear correlation with incremental increases in prostate volume (B=0.181, P=0.004). Abdominal obesity as determined by anthropometric measures including body mass index (odds ratio [OR], 1.205; 95% confidence interval [CI], 1.088-1.336), waist circumference (OR, 1.073; 95% CI, 1.032-1.115), body fat (OR, 1.126; 95% CI, 1.056-1.202), and visceral fat composition (OR, 1.667; 95% CI, 1.246-2.232) was significantly associated with the presence of high-volume benign prostatic hyperplasia (BPH) (prostate volume≥ 40 mL). Furthermore, the highest quartile of serum leptin (OR, 3.541; 95% CI, 1.103-11.365) and adiponectin levels (OR, 0.315; 95% CI, 0.102-0.971) were significantly correlated with high-volume BPH compared to the lowest quartile of levels.
CONCLUSIONS
Abdominal obesity and serum leptin level are positively associated with prostate growth, whereas serum adiponectin level is inversely associated with the presence of prostatic enlargement.
Keyword
MeSH Terms
-
Adiponectin
Adipose Tissue
Atherosclerosis
Body Mass Index
Cohort Studies*
Epidemiology
Genome
Humans
Intra-Abdominal Fat
Korea*
Leptin
Male
Mass Screening
Obesity*
Obesity, Abdominal
Prostate
Prostate-Specific Antigen
Prostatic Diseases
Prostatic Hyperplasia
Retrospective Studies*
Risk Factors*
Testosterone
Ultrasonography
Waist Circumference
Adiponectin
Leptin
Prostate-Specific Antigen
Testosterone
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