Ann Lab Med.  2015 May;35(3):376-378. 10.3343/alm.2015.35.3.376.

T618I-Mutated Colony Stimulating Factor 3 Receptor in Chronic Neutrophilic Leukemia and Chronic Myelomonocytic Leukemia Patients who Underwent Allogeneic Stem Cell Transplantation

• Lee SE
• Jo I
• Jang W
• Kim Y
• Han K
• Kim M

• KMID: 2363215
• DOI: http://doi.org/10.3343/alm.2015.35.3.376

Abstract

No abstract available.

MeSH Terms

Adult
Bone Marrow/pathology
DNA Mutational Analysis
Humans
Leukemia, Myelomonocytic, Chronic/*diagnosis/genetics/therapy
Leukemia, Neutrophilic, Chronic/*diagnosis/genetics/therapy
Leukocyte Disorders/diagnosis
Male
Middle Aged
Mutation
Prognosis
Receptors, Colony-Stimulating Factor/*genetics
Recurrence
*Stem Cell Transplantation
Transplantation, Homologous
Receptors, Colony-Stimulating Factor

Figure

• 

  Fig. 1 Chronic neutrophilic leukemia; (A) peripheral blood showing neutrophilia with toxic granulation (Wright-Giemsa staining, ×1,000) and (B) bone marrow biopsy showing a markedly elevated myeloid:erythroid ratio. Chronic myelomonocytic leukemia (Hematoxylin and eosin staining, ×1,000); (C) peripheral blood with monocytosis and neutrophilia (Wright-Giemsa staining, ×400) and (D) bone marrow aspirate with erythroid and granulocytic dysplasia (Wright-Giemsa staining, ×1,000).

• 

  Fig. 2 Sequencing of genomic DNA isolated from peripheral blood leukocytes, demonstrating the CSF3R c.1853C>T (p.Thr618Ile) mutation. The CSF3R T618I mutation was detected in patient #1 with CNL, pre-allo-SCT (A) and in patient #2 with CMML at diagnosis (B). After allo-SCT, the mutation was not detected in patient #1 (C) and in patient #2 (D).Abbreviations: CNL, chronic neutrophilic leukemia; allo-SCT, allogeneic stem cell transplantation; CMML, chronic myelomonocytic leukemia.

Reference

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