Ann Dermatol.  2019 Dec;31(6):673-677. 10.5021/ad.2019.31.6.673.

Leukemia Cutis in Chronic Neutrophilic Leukemia Associated with Colony Stimulating Factor 3 Receptor Mutation: Clinical Severity Paralleled with Hematologic Abnormality

• Kwon O
• Park J
• Chung H
• Park KD

• KMID: 2461992
• DOI: http://doi.org/10.5021/ad.2019.31.6.673

Abstract

Cutaneous lesions of leukemia cutis (LC) by chronic neutrophilic leukemia (CNL) have been merely reported due to the rare occurrences of CNL. Furthermore cutaneous lesions in relation to clinical severity have been far less studied. A 70-year-old man presented with multiple violaceous papules and excoriations on both lower extremities. The diagnosis was LC based on histologic and laboratory evaluation and the origin was elaborated as CNL with the confirmation of colony stimulating factor 3 receptor (CSF3R) mutation. Interestingly, the patient presented clinical severity in a parallel manner to the hematologic abnormality. To the best of our knowledge, there has been no reported case of CSF3R confirmed LC in CNL featuring explicit skin eruption in relation to laboratory findings.

Keyword

Colony-stimulating factors 3 receptor; Leukemia cutis; Leukemia, neutrophilic, chronic

MeSH Terms

Aged
Colony-Stimulating Factors*
Diagnosis
Humans
Leukemia*
Leukemia, Neutrophilic, Chronic*
Lower Extremity
Skin
Colony-Stimulating Factors