Korean J Hematol.
1999 Nov;34(4):625-629.
A Case of Invasive Pulmonary Aspergillosis Cured with Liposomal Amphotericin, Granulocyte Transfusion and Surgery in an Allogeneic Hemopoietic Stem Cell Transplantation Recipient
- Affiliations
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- 1Department of Internal Medicine, College of Medicine, Pochon CHA University, Pochon, Korea.
- 2Department of Clinical Pathology, College of Medicine, Pochon CHA University, Pochon, Korea.
- 3Department of Anatomical Pathology, College of Medicine, Pochon CHA University, Pochon, Korea.
Abstract
- The prognosis of invasive aspergillosis in allogeneic bone marrow transplantation recipients is grave in the absence of bone marrow recovery in spite of antifungal treatment with amphotericin B. Beneficial role of granulocyte transfusion in neutropenic patients with fungal infection has been re-evaluated since granulocyte colony-stimulating factor made effective collection of granulocyte possible. And Liposomal amphotericin appears to be an effective alternative to conventional amphotericin B with much less toxicity. A 34-year-old patient with acute lymphoblastic leukemia developed invasive pulmonary aspergillosis during very early period of allogeneic hemopoietic stem cell transplantation. We treated the case successfully with liposomal amphotericin and granulocyte transfusion and surgery in spite of known high mortality of invasive aspergillosis in transplantation patients.
Keyword
MeSH Terms
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Adult
Amphotericin B*
Aspergillosis
Bone Marrow
Bone Marrow Transplantation
Granulocyte Colony-Stimulating Factor
Granulocytes*
Humans
Invasive Pulmonary Aspergillosis*
Leukemia
Mortality
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Prognosis
Stem Cell Transplantation*
Stem Cells*
Amphotericin B
Granulocyte Colony-Stimulating Factor
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