Infect Chemother.  2003 Oct;35(5):332-336.

Two Cases of Aspergillus Endocarditis in Patients with Acute Lymphoblastic Leukemia

• Shin SC
• Peck KR
• Hong JJ
• Song BG
• Kim DH
• Jeon K
• Chae JW
• Son JS
• Jung SI
• Oh WS
• Song JH

Abstract

Although Aspergillus endocarditis has rarely been reported, it can cause fatal complications in hematologic malignancy patients and allogeneic stem cell transplant recipients. We experienced two cases of aspergillus endocarditis developed in acute lymphoblastic leukemia patients. Case; A 19-year-old patient developed Aspergillus endocarditis after allogenic hemopoietic stem cell transplantation. He was treated with surgical intervention and liposomal amphotericin B. He died of recurred Aspergillus endocarditis and cerebral hemorrhage probably related with aspergillosis of central nervous system. Case 2; A 23-year-old patient developed invasive Aspergillus endocarditis after induction chemotherapy. Aspergillus endocarditis was successfully treated by surgical intervention and amphotericin B. He died of refractory neutropenic fever and sepsis after the third relapse of leukemia and repetitive chemotherapy. He probably had invasive pulmonary aspergillosis without evidence of endocarditis recurrence. Because the mortality of Aspergillus endocarditis is very high, early diagnosis and surgical intervention are very important for better outcome.

Keyword

Aspergillosis; Leukemia; Endocarditis; Osteomyelitis

MeSH Terms

Amphotericin B
Aspergillosis
Aspergillus*
Central Nervous System
Cerebral Hemorrhage
Drug Therapy
Early Diagnosis
Endocarditis*
Fever
Hematologic Neoplasms
Humans
Induction Chemotherapy
Invasive Pulmonary Aspergillosis
Leukemia
Mortality
Osteomyelitis
Precursor Cell Lymphoblastic Leukemia-Lymphoma*
Recurrence
Sepsis
Stem Cell Transplantation
Stem Cells
Transplantation
Young Adult
Amphotericin B