Ann Dermatol.  1990 Jan;2(1):43-46. 10.5021/ad.1990.2.1.43.

Acquired Reactive Perforating Collagenosis of Diabetes Mellitus and Chronic Renal Failure

• Chun TJ
• Kim MN
• Song KY
• Ro BI
• Chang CY

• KMID: 2362057
• DOI: http://doi.org/10.5021/ad.1990.2.1.43

Abstract

We report, herein, a case of reactive perforating collagenosis in a 52-year-old man with diabetes mellitus and chronic renal failure on hemodialysis. He had multiple, pinhead to pea sized, round or oval shaped, central umbilicated papules on the face, trunk, and extremities for 3 months duration. The papules developed after scratching due to pruritus. Histopathologic examination showed a cup-shaped depression of the epidermis filled with parakeratotic material, necrobiotic collagen and inflammatory cells. At the base of the depression, the epidermis showed interruption through which basophilic bundles of collagen ex-tend in a vertical direction from the dermis. The skin lesions improved after treatment with oral antihistaminics:

Keyword

Chronic renal failure; Diabetes mellitus; Reactive perforating collagenosis

MeSH Terms

Basophils
Collagen
Depression
Dermis
Diabetes Mellitus*
Epidermis
Extremities
Humans
Kidney Failure, Chronic*
Middle Aged
Peas
Pruritus
Renal Dialysis
Skin
Collagen