Ann Dermatol.  1996 Jul;8(3):201-205. 10.5021/ad.1996.8.3.201.

A Case of Malignant Histiocytosis

• Hong MH
• Park JJ
• Kang IK
• Choi KC
• Lim SC

• KMID: 2360490
• DOI: http://doi.org/10.5021/ad.1996.8.3.201

Abstract

Malignant histiocytosis is a rare, usually fatal malignant neoplasm of reticuloendothelial systems. The disease is associated with fever, malaise, weight loss, hepatosplenomegaly, lymphadenopathy, pancytopenia, jaundice, and purpura. A 44-year-old female patient is described who had multiple, purple crusted nodules and plaques in the skin. In the laboratory study, pancytopenia was noted on the peripheral blood. In addition many atypical histiocytes were seen on the bone marrow aspiration. A lesional biopsy showed nodular infiltrations of atypical histiocytes in the dermis and some erythrophagocytosis was seen. Immunohistochemically, the histiocytes were weakly stained for lysozyme and α-l-antichymotrypsin, but were unstained for S-100 protein, cytokeratin, CEA(carcinoembryonic antigen), pan T/B marker CD30(ki-1), UCHL-1 LCA(leukocyte common antigen), and α-l-antitrypsin.

Keyword

Atypical histiocytes; Malignant histiocytosis

MeSH Terms

Adult
Biopsy
Bone Marrow
Dermis
Female
Fever
Histiocytes
Histiocytic Sarcoma*
Humans
Jaundice
Keratins
Lymphatic Diseases
Mononuclear Phagocyte System
Muramidase
Pancytopenia
Purpura
S100 Proteins
Skin
Weight Loss
Keratins
Muramidase
S100 Proteins