J Gynecol Oncol.  2016 Mar;27(2):e21. 10.3802/jgo.2016.27.e21.

Clinical significance of human papillomavirus genotyping

• Choi YJ
• Park JS

• KMID: 2360251
• DOI: http://doi.org/10.3802/jgo.2016.27.e21

Abstract

Cervical cancer is the fourth most common cancer in women worldwide, and the human papillomavirus (HPV) is the main causative agent for its development. HPV is a heterogeneous virus, and a persistent infection with a high-risk HPV contributes to the development of cancer. In recent decades, great advances have been made in understanding the molecular biology of HPV, and HPV\'s significance in cervical cancer prevention and management has received increased attention. In this review, we discuss the role of HPV genotyping in cervical cancer by addressing: clinically important issues in HPV virology; the current application of HPV genotyping in clinical medicine; and potential future uses for HPV genotyping.

Keyword

DNA Tests; Genotype; Human Papillomavirus; Uterine Cervical Neoplasms; Vaccine

MeSH Terms

DNA, Viral/*analysis
Early Detection of Cancer/*methods
Female
*Genome, Viral
Genotype
Humans
Papillomaviridae/classification/*genetics
Papillomavirus Infections/complications/drug therapy/*virology
Papillomavirus Vaccines/therapeutic use
Uterine Cervical Neoplasms/diagnosis/drug therapy/*virology
DNA, Viral
Papillomavirus Vaccines