Korean J Radiol.  2016 Apr;17(2):281-288. 10.3348/kjr.2016.17.2.281.

F-18 Sodium Fluoride Positron Emission Tomography/Computed Tomography for Detection of Thyroid Cancer Bone Metastasis Compared with Bone Scintigraphy

Affiliations
  • 1Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul 13620, Korea. wwlee@snu.ac.kr
  • 2World Class University, Department of Molecular Medicine and Biopharmaceutical Science, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 03080, Korea.
  • 3Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul 03087, Korea.
  • 4Department of Pathology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul 13620, Korea.

Abstract


OBJECTIVE
The aim of the study was to compare the diagnostic performances of F-18 sodium fluoride positron emission tomography/computed tomography (bone PET/CT) and bone scintigraphy (BS) for the detection of thyroid cancer bone metastasis.
MATERIALS AND METHODS
We retrospectively enrolled 6 thyroid cancer patients (age = 44.7 ± 9.8 years, M:F = 1:5, papillary:follicular = 2:4) with suspected bone metastatic lesions in the whole body iodine scintigraphy or BS, who subsequently underwent bone PET/CT. Pathologic diagnosis was conducted for 4 lesions of 4 patients.
RESULTS
Of the 17 suspected bone lesions, 10 were metastatic and 7 benign. Compared to BS, bone PET/CT exhibited superior sensitivity (10/10 = 100% vs. 2/10 = 20%, p = 0.008), and accuracy (14/17 = 82.4% vs. 7/17 = 41.2%, p < 0.025). The specificity (4/7 = 57.1%) of bone PET/CT was not significantly different from that of BS (5/7 = 71.4%, p > 0.05).
CONCLUSION
Bone PET/CT may be more sensitive and accurate than BS for the detection of thyroid cancer bone metastasis.

Keyword

Thyroid cancer; Bone metastasis; Bone scintigraphy; F-18 sodium fluoride; Positron emission tomography

MeSH Terms

Adult
Bone Neoplasms/*radiography/secondary
Bone and Bones/*radiography
Contrast Media/*chemistry
Female
Fluorine Radioisotopes/chemistry
Humans
Male
Middle Aged
Positron-Emission Tomography
Retrospective Studies
Sodium Fluoride/*chemistry
Thyroid Neoplasms/*pathology
Tomography, X-Ray Computed
Whole Body Imaging
Contrast Media
Fluorine Radioisotopes
Sodium Fluoride
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