Nucl Med Mol Imaging.  2018 Aug;52(4):318-323. 10.1007/s13139-018-0527-8.

Bone and Calcified Soft Tissue Metastases of Medullary Thyroid Carcinoma Better Characterized on ¹⁸F-Fluoride PET/CT than on ⁶⁸Ga-Dotatate PET/CT

• Duarte PS
• de Castroneves LA
• Sado HN
• Sapienza M
• de Oliveira Hoff AAF
• Buchpiguel CA

• KMID: 2418996
• DOI: http://doi.org/10.1007/s13139-018-0527-8

Abstract

Herein, we report a case of a 19-year-old man with multiple endocrine neoplasia type 2B (MEN2B) and medullary thyroid carcinoma (MTC) diagnosed when he was 12 years of age. The patient had previously undergone total thyroidectomy, cervical radiotherapy, and chemotherapy. He progressed with known bone, pulmonary, and lymph node metastases and was scanned with ¹â¸F-fluoride (¹â¸F-NaF) and ⁶⁸Ga-dotatate whole-body positron emission tomography/computed tomography (PET/CT) for metastatic disease monitoring.We found that the MTC bone metastases and soft tissue calcified metastases were better characterized on ¹â¸F-NaF PET/CT than on ⁶⁸Ga-dotatate PET/CT. This case illustrates that the ¹â¸F-NaF PET/CT could be helpful not only to the detection of bone metastases but also to the detection of calcified soft tissue metastases in patients with MTC.

Keyword

Medullary thyroid carcinoma; Gallium-68; ⁶⁸Ga; ¹⁸F; ¹⁸F-NaF; PET/CT

MeSH Terms

Drug Therapy
Electrons
Humans
Lymph Nodes
Multiple Endocrine Neoplasia Type 2b
Neoplasm Metastasis*
Positron-Emission Tomography and Computed Tomography*
Radiotherapy
Thyroid Gland*
Thyroid Neoplasms*
Thyroidectomy
Young Adult