Diabetes Metab J.  2016 Oct;40(5):386-395. 10.4093/dmj.2016.40.5.386.

Effects of Body Weight Reduction on Serum Irisin and Metabolic Parameters in Obese Subjects

• Fukushima
• Kurose S
• Shinno H
• Thi Thu HC
• Takao N
• Tsutsumi H
• Hasegawa T
• Nakajima T
• Kimura Y

• KMID: 2354612
• DOI: http://doi.org/10.4093/dmj.2016.40.5.386

Abstract

BACKGROUND
Irisin is a myokine implicated in lipid and glucose metabolism. The objective of this study is to examine the effect of a body weight reduction on the serum irisin level and physical indicators in obese Japanese patients without diabetes.
METHODS
The subjects were 22 patients (male/female, 5/17; age, 46.1±16.0 years; body mass index [BMI], 36.9±5.0 kg/m²) who completed a 6-month body weight reduction program at our clinic. The program included diet, exercise therapy and cognitive behavioral therapy. Blood parameters, body composition, exercise tolerance, homeostasis model assessment of insulin resistance (HOMA-IR), and serum irisin were determined before and after intervention, and relationships among changes in these data were examined.
RESULTS
There were significant decreases in body weight and BMI after the intervention. Irisin before the intervention was significantly positively correlated with HOMA-IR (r=0.434, P<0.05). The mean irisin level showed no significant change after the intervention in all participants. However, improvements in % body fat, subcutaneous fat area, triglycerides, and fasting glucose were significantly greater in patients with an increase in irisin compared to those with a decrease in irisin after the intervention. Patients with an increase in irisin also had significantly lower fasting insulin (9.7±4.8 vs. 16.4±8.2, P<0.05) and HOMA-IR (2.2±1.1 vs. 3.7±1.6, P<0.05) after the intervention, compared to patients with a decrease in irisin.
CONCLUSION
Body weight reduction did not alter irisin levels. However, irisin may play important roles in fat and glucose metabolism and insulin resistance, and the effects of body weight reduction on irisin kinetics may be a key for obesity treatment.

Keyword

Body composition; Insulin resistance; Irisin; Lean muscle mass; Obesity

MeSH Terms

Adipose Tissue
Asian Continental Ancestry Group
Body Composition
Body Mass Index
Body Weight*
Cognitive Therapy
Diet
Exercise Therapy
Exercise Tolerance
Fasting
Glucose
Homeostasis
Humans
Insulin
Insulin Resistance
Kinetics
Metabolism
Obesity
Subcutaneous Fat
Triglycerides
Glucose
Insulin
Triglycerides

Figure

• 

  Fig. 1 Relationship between irisin and homeostasis model assessment of insulin resistance (HOMA-IR) before intervention in all subjects. Partial correlation analysis was performed using gender as a control variable.

• 

  Fig. 2 Changes of serum irisin before and after the intervention in subjects with (A) an increase in irisin and (B) a decrease in irisin.

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