Biomol Ther.  2016 Sep;24(5):552-558. 10.4062/biomolther.2015.200.

Inhibitory Effects of Norwogonin, Oroxylin A, and Mosloflavone on Enterovirus 71

• Choi HJ
• Song HH
• Lee JS
• Ko HJ
• Song JH

• KMID: 2351681
• DOI: http://doi.org/10.4062/biomolther.2015.200

Abstract

Severe complications associated with EV71 infections are a common cause of neonatal death. Lack of effective therapeutic agents for these infections underlines the importance of research for the development of new antiviral compounds. In the present study, the anti-EV71 activity of norwogonin, oroxylin A, and mosloflavone from Scutellaria baicalensis Georgi was evaluated using a cytopathic effect (CPE) reduction method, which demonstrated that all three compounds possessed strong anti-EV71 activity and decreased the formation of visible CPEs. Norwogonin, oroxylin A, and mosloflavone also inhibited virus replication during the initial stage of virus infection, and they inhibited viral VP2 protein expression, thereby inhibiting viral capsid protein synthesis. However, ribavirin has a relatively weaker efficacy compared to the other drugs. Therefore, these findings provide important information that will aid in the utilization of norwogonin, oroxylin A, and mosloflavone for EV71 treatment.

Keyword

Enterovirus 71; Antiviral activity; Norwogonin; Oroxylin A; Mosloflavone

MeSH Terms

Capsid Proteins
Enterovirus*
Methods
Perinatal Death
Ribavirin
Scutellaria baicalensis
Virus Replication
Capsid Proteins
Ribavirin