- The Evaluation of Skin Safety and Skin Cell Toxicity for Scutellaria baicalensis Georgi Extract according to Extraction Conditions
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Kim HM, Lim YY, Cho SM, Kim MY, Son IP, Suk JM, Park JO, Park JH, Cho JW, Kim BJ
- KMID: 2302398
- Korean J Dermatol.
- 2012 Nov;50(11):959-968.
BACKGROUND: Scutellaria baicalensis Georgi extract is used as a traditional herbal medicine. The efficacy of Scutellaria baicalensis Georgi extract is known for antioxidative activity, antiinflammation effect, antibacterial effect, inhibitory effect... -
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- Scutellaria baicalensis Inhibits Mast Cell-Mediated Anaphylactic Reactions
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Choi YH, Han EH, Chai OH, Kim YK, Kim HT, Song CH
- KMID: 1462534
- Korean J Phys Anthropol.
- 2010 Dec;23(4):217-227.
Mast cells play a critical role in the effector phase of immediate hypersensitivity and allergic diseases. Scutellaria baicalensis is a widely used herb in traditional oriental medicine with anticancer, antiviral,... -
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- A combinational effect of acetaminophen and oriental herbs on the regulation of inflammatory mediators in microglia cell line, BV2
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Kim H, Bae S, Kwon KY, Hwang YI, Kang JS, Lee WJ
- KMID: 2133263
- Anat Cell Biol.
- 2015 Dec;48(4):244-250.
- doi: 10.5115/acb.2015.48.4.244
The mechanism of Western medicine that is commonly used for pain relief is well-known. However, very little is known for oriental herbs, and even less is known for mixture of... -
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- Baicalein, wogonin, and Scutellaria baicalensis ethanol extract alleviate ovalbumin-induced allergic airway inflammation and mast cell-mediated anaphylactic shock by regulation of Th1/Th2 imbalance and histamine release
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Bui TT, Piao CH, Song CH, Lee CH, Shin HS, Chai OH
- KMID: 2451238
- Anat Cell Biol.
- 2017 Jun;50(2):124-134.
- doi: 10.5115/acb.2017.50.2.124
Asthma is characterized by chronic inflammation, goblet cell hyperplasia, the aberrant production of the Th2 cytokines, and eosinophil infiltration into the lungs. In this study, we examined the effects of... -
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- Induction of Apoptosis Scutellaria baicalensis Georgi Root Extract by Inactivation of the Phosphatidyl Inositol 3-kinase/Akt Signaling Pathway in Human Leukemia U937 Cells
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Choi EO, Hwang HJ, Choi YH
- KMID: 2447436
- J Cancer Prev.
- 2019 Mar;24(1):11-19.
- doi: 10.15430/JCP.2019.24.1.11
BACKGROUND: The roots of Scutellaria baicalensis Georgi (Labiatae) have been widely used in traditional medicine for treatment of various diseases. In this study, we investigated the effects of ethanol extracts... -
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- Effect of Scutellaria baicalensis Extract on the Immune Functions, Microbial Growth and Mutagenicity
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Lee JH, Shin SJ, Moon Y
- KMID: 1928286
- Korean J Immunol.
- 1998 Sep;20(3):343-348.
Scute/larisa baica/ensis (SB) has been used as a folk medicine for curing ulcer, inflammation and infection. However, surprisingly little has been done to develop and exploit SB's immunomodulating, anti- inflammatory... -
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- The Effect of LDL Oxidation Caused an Atherosclerosis in Macrophage Cells * : The Antioxidant Effect of Ganhaungenin
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Her E, Lee ST, Cho SI, Park DK
- KMID: 2082999
- Korean J Immunol.
- 1997 Sep;19(3):337-346.
Oxidatively modified low density lipoprotein (LDL) could contribute to one of the atherosclerotic processes through its uptake by the scavenger receptor of macrophage. The aim of the present study was... -
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- Inhibitory Effects of Norwogonin, Oroxylin A, and Mosloflavone on Enterovirus 71
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Choi HJ, Song HH, Lee JS, Ko HJ, Song JH
- KMID: 2351681
- Biomol Ther.
- 2016 Sep;24(5):552-558.
- doi: 10.4062/biomolther.2015.200
Severe complications associated with EV71 infections are a common cause of neonatal death. Lack of effective therapeutic agents for these infections underlines the importance of research for the development of... -
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- The Molecular Mechanism of Baicalin on RANKL-induced Osteoclastogenesis in RAW264.7 Cells
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Ko SY
- KMID: 1431096
- Int J Oral Biol.
- 2013 Jun;38(2):67-72.
This study examined the anti-osteoclastogenic effects of baicalin on receptor activator of NF-kB ligand (RANKL)-induced RAW264.7 cells. Baicalin is a flavonoid that is produced by Scutellaria baicalensis and is known... -
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- Anti-Allergic Effect of Oroxylin A from Oroxylum indicum Using in vivo and in vitro Experiments
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Lee AY, Kang S, Park SJ, Huang J, Im DS
- KMID: 2164220
- Biomol Ther.
- 2016 May;24(3):283-290.
- doi: 10.4062/biomolther.2016.071
Oroxylum indicum has long been used in Asian traditional medicine to prevent and treat respiratory diseases, diabetes, diarrhea and other conditions. Oroxylin A is a flavone that is present in... -
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- Baicalein Protects Human Skin Cells against Ultraviolet B-Induced Oxidative Stress
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Oh MC, Piao MJ, Fernando P, Han X, Hewage SR, Park JE, Ko MS, Jung U, Kim IG, Hyun JW
- KMID: 2374616
- Biomol Ther.
- 2016 Nov;24(6):616-622.
- doi: 10.4062/biomolther.2016.022
Baicalein (5,6,7-trihydroxy-2-phenyl-chromen-4-one) is a flavone, a type of flavonoid, originally isolated from the roots of Scutellaria baicalensis. This study evaluated the protective effects of baicalein against oxidative damage-mediated apoptosis induced... -
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- Detection of Inhibitors of beta-Amyloid Peptide Aggregation in Plant Extracts
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Chung MA, Chay KO, Ahn BW
- KMID: 2172400
- Chonnam Med J.
- 2001 Dec;37(4):367-376.
The aggregated beta-amyloid peptides (betaAPs) are suggested to be important in the pathogenesis of Alzheimer's disease. In this study, inhibitory effects of plant extracts on beta-AP aggregation were examined using... -
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- Baicalein Protects 6-OHDA-induced Neuronal Damage by Suppressing Oxidative Stress
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Im HI, Nam E, Lee ES, Hwang YJ, Kim YS
- KMID: 1587469
- Korean J Physiol Pharmacol.
- 2006 Dec;10(6):309-315.
The protective effects of baicalein, one of the flavonoids in Scutellaria baicalensis Georgi, were evaluated against 6-hydroxydopamine (6-OHDA)-induced neuronal damage in mice and cultured human neuroblastoma cells. Nigrostriatal damage was... -
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- Effects of Baicalin on Oral Pharmacokinetics of Caffeine in Rats
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Noh K, Nepal MR, Jeong KS, Kim SA, Um YJ, Seo CS, Kang MJ, Park PH, Kang W, Jeong HG, Jeong TC
- KMID: 2380355
- Biomol Ther.
- 2015 Mar;23(2):201-206.
- doi: 10.4062/biomolther.2014.134
Scutellaria baicalensis is one of the most widely used herbal medicines in East Asia. Because baicalein and baicalin are major components of this herb, it is important to understand the... -
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- Comprehensive Evaluation of the Anti-Helicobacter pylori Activity of Scutellariae Radix
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Lee BW, Park IH, Yim D, Choi SS
- KMID: 2376499
- Nat Prod Sci.
- 2017 Mar;23(1):46-52.
- doi: 10.20307/nps.2017.23.1.46
The aim of this study was to evaluate the anti-Helicobacter pylori activity of fractions and major aglycon compounds (baicalein, chrysin, oroxylin A, wogonin) of Scutellariae Radix. Minimum inhibitory concentration (MIC)... -
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- Single-Dose Oral Toxicity of Fermented Scutellariae Radix Extract in Rats and Dogs
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Kim MS, Ham SH, Kim JH, Shin JE, Oh J, Kim TW, Yun HI, Lim JH, Jang BS, Cho JH
- KMID: 1432310
- Toxicol Res.
- 2012 Dec;28(4):263-268.
The aim of this study was to investigate the acute oral toxicity of fermented Scutellariae Radix (JKTMHGu-100) in rats and dogs. JKTM-HGu-100 was orally administered at a dose of 2,000... -
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- Chronic Administration of Baicalein Decreases Depression-Like Behavior Induced by Repeated Restraint Stress in Rats
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Lee B, Sur B, Park J, Kim SH, Kwon S, Yeom M, Shim I, Lee H, Hahm DH
- KMID: 1500233
- Korean J Physiol Pharmacol.
- 2013 Oct;17(5):393-403.
- doi: 10.4196/kjpp.2013.17.5.393
Baicalein (BA), a plant-derived active flavonoid present in the root of Scutellaria baicalensis, has been widely used for the treatment of stress-related neuropsychiatric disorders including depression. Previous studies have demonstrated... -
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- Baicalein Inhibits the Migration and Invasion of B16F10 Mouse Melanoma Cells through Inactivation of the PI3K/Akt Signaling Pathway
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Choi EO, Cho EJ, Jeong JW, Park C, Hong SH, Hwang HJ, Moon SK, Son CG, Kim WJ, Choi YH
- KMID: 2375042
- Biomol Ther.
- 2017 Mar;25(2):213-221.
- doi: 10.4062/biomolther.2016.094
Baicalein, a natural flavonoid obtained from the rhizome of Scutellaria baicalensis Georgi, has been reported to have anticancer activities in several human cancer cell lines. However, its antimetastatic effects and... -
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- Baicalein Inhibits Dextran Sulfate Sodium-induced Mouse Colitis
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Zhong X, Surh YJ, Do SG, Shin E, Shim KS, Lee CK, Na HK
- KMID: 2454672
- J Cancer Prev.
- 2019 Jun;24(2):129-138.
- doi: 10.15430/JCP.2019.24.2.129
BACKGROUND: Baicalein is a bioactive flavone that is originally extracted from the root of Scutellaria baicalensis Georgi. This plant has long served as Chinese herbal medicine in the management of... -
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- Immunoregulatory Effects of Water Extracts of Scutellariae Radix in DSS-Induced Inflammatory Bowel Disease Animal Model
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Lee SH, Lim BO, Choue RW
- KMID: 2078293
- Korean J Nutr.
- 2004 Jul;37(6):431-439.
Scutellariae Radix (Scu.), one of the immune-regulatory substances, is recognized to play the role in the metabolic process of inflammation, allergy and immunity. It has been traditionally used in the... -
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