Biomol Ther.  2016 Sep;24(5):469-474. 10.4062/biomolther.2015.214.

Pharmacological Activities and Applications of Spicatoside A

• Ramalingam M
• Kim SJ

• KMID: 2351669
• DOI: http://doi.org/10.4062/biomolther.2015.214

Abstract

Liriopogons (Liriope and Opiopogon) species are used as a main medicinal ingredient in several Asian countries. The Liriopes Radix (tuber, root of Liriope platyphylla) has to be a promising candidate due to their source of phytochemicals. Steroidal saponins and their glycosides, phenolic compounds, secondary metabolites are considered of active constituents in Liriopes Radix. Spicatoside A, a steroidal saponin, could be more efficacious drug candidate in future. In this review, we summarized the available knowledge on phytochemical and pharmacological activities for spicatoside A. It significantly suppressed the level of NF-κB, NO, iNOS, Cox-2, IL-1β, IL-6 and MAPKs in LPS-stimulated inflammation. The production of MUC5AC mucin was increased. MMP-13 expression was down-regulated in IL-1β-treated cells and reduced glycosaminoglycan release from IL-1α-treated cells. The neurite outgrowth activity, PI3K, Akt, ERK1/2, TrkA and CREB phosphorylation and neurotropic factors such as NGF and BDNF were upregulated with increased latency time. It also showed cell growth inhibitory activity on various carcinoma cells. From this, spicatoside A exerts anti-inflammation, anti-asthma, anti-osteoclastogenesis, neurite outgrowth, memory consolidation and anticancer activities. Further studies are needed on spicatoside A in order to understand mechanisms of action to treat various human diseases.

Keyword

Liriopes; Saponins; L. platypylla; Neurite outgrowth; Memory consolidation; Anti-inflammatory

MeSH Terms

Asian Continental Ancestry Group
Brain-Derived Neurotrophic Factor
Glycosides
Humans
Inflammation
Interleukin-6
Memory Consolidation
Mucins
Nerve Growth Factor
Neurites
Phenol
Phosphorylation
Phytochemicals
Saponins
Brain-Derived Neurotrophic Factor
Glycosides
Interleukin-6
Mucins
Nerve Growth Factor
Phenol
Saponins