J Korean Neurol Assoc.  2013 Nov;31(4):270-272.

Cyclosporine-Induced Posterior Reversible Leukoencephalopathy Syndrome With Reduced Cerebral Perfusion

Affiliations
  • 1Department of Neurology, Pusan National University Hospital, Pusan National University Graduate School of Medicine, Busan, Korea. chohj75@gmail.com

Abstract

Posterior reversible leukoencephalopathy syndrome (PRLS) is a disorder that is characterized by reversible white-matter edema affecting the posterior regions of the brain. There are rare cases in which cyclosporine has been cited as a medication responsible for PRLS, which causes hypoperfused ischemia by endothelial injury and vasoconstriction, with resultant vasogenic edema. A PRLS patient in whom the condition was induced by cyclosporine is described herein. Perfusion computed tomography revealed a clinically relevant hypoperfused area, including the zones of vasogenic edema.

Keyword

Posterior reversible leukoencephalopathy syndrome; Cyclosporine; Perfusion computed tomography

MeSH Terms

Brain
Cyclosporine
Edema
Humans
Ischemia
Leukoencephalopathies*
Perfusion*
Vasoconstriction
Cyclosporine
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