Ann Dermatol.  2015 Aug;27(4):454-456. 10.5021/ad.2015.27.4.454.

Cyclosporine-Induced Posterior Reversible Encephalopathy Syndrome in a Patient with Pemphigus Vulgaris

• Park SE
• Lee JY
• Shin SJ
• Kim CW
• Kim SS

• KMID: 2171508
• DOI: http://doi.org/10.5021/ad.2015.27.4.454

Abstract

No abstract available.

MeSH Terms

Humans
Pemphigus*
Posterior Leukoencephalopathy Syndrome*

Figure

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  Fig. 1 (A) Axial T2-weighted magnetic resonance imaging (MRI) showing an area of high signal intensity in the bilateral white matter of the posterior parieto-occipital area. (B) Six weeks later, axial T2-weighted MRI showing significant improvement after cyclosporine withdrawal.

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  Fig. 2 (A) Highly crusted vegetating lesions on the lower lip. (B) Several flaccid blisters and scaly crusted erosions are distributed on her trunk. (C) Separation of the epidermis above the basal layer and scattered acantholytic cells (H&E, ×200). (D) Direct immunofluorescence study of the perilesional skin shows intercellular deposition of immunoglobulin G (×100).

Reference

1. Amor KT, Ryan C, Menter A. The use of cyclosporine in dermatology: part I. J Am Acad Dermatol. 2010; 63:925–946.

2. Adams DH, Ponsford S, Gunson B, Boon A, Honigsberger L, Williams A, et al. Neurological complications following liver transplantation. Lancet. 1987; 1:949–951.

3. Hinchey J, Chaves C, Appignani B, Breen J, Pao L, Wang A, et al. A reversible posterior leukoencephalopathy syndrome. N Engl J Med. 1996; 334:494–500.

4. Belli LS, De Carlis L, Romani F, Rondinara GF, Rimoldi P, Alberti A, et al. Dysarthria and cerebellar ataxia: late occurrence of severe neurotoxicity in a liver transplant recipient. Transpl Int. 1993; 6:176–178.