J Korean Neurol Assoc.
2001 Jul;19(4):435-437.
Two Cases of Simvastatin-induced Acute Myopathy
- Affiliations
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- 1Department of Neurology, Yonsei University Medical College.
- 2Department of Neurology, College of Medicine, Gyeongsang National University.
Abstract
- Among the side effects of simvastatin, elevated liver enzyme or creatine kinase activity has been occasionally report-ed, but overt myopathy is rare. We report two cases of simvastatin-induced myopathy with usual dosages of simvas-tatin. Two patients presented with general myalgia, markedly elevated creatine kinase activity, and mild proximal weak-ness. One patient had been treated with concomitant use of cyclosporine and simvastatin after renal transplantation, and another patient had diabetic nephropathy. We recommend careful monitoring when myalgia appears in a patient receiv-ing simvastatin. (J Korean Neurol Assoc 19(4):435~437, 2001)
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