J Korean Neurol Assoc.  1994 Sep;12(3):542-551.

Clinical Experience of Subacute Sclerosing Panencephalitis treated with Alpha-interferon and Ionsiplex

Affiliations
  • 1Department of Neurology, Pusan National University, Korea.

Abstract

Subacute sclerosing panencephalitis (SSPE) is a slowly progressing, chronic persistent fatal central nervous system disease, involving gray and white matter, especially white matter caused by measles virus that affecting children and young adult. 45 to 68% of affected individuals had measles before the age of 2. Current knowledge of the pathogenesis of SSPE involves mutation of the measles virus, resulting in lack of production of the M(Matrix)-protein. No therapeutic maneuvour gas been proven conclusively to be of value. But recently intraventricular alpha-interferon (a-IFN) injection combined with oral inosiplex increase the length of survival and may bring remission or stabilization in SSPE. We report a case of SSPE which was diagnosed by history, clinical manifestation, typical EEG findings, high titer of measles antibodies in cerebrospinal fluid and serum by hemagglutinin inhibition method. We tried intraventricular a-IFN injection via Ommaya reservoir and oral inosiplex.


MeSH Terms

Antibodies
Central Nervous System
Cerebrospinal Fluid
Child
Electroencephalography
Hemagglutinins
Humans
Inosine Pranobex
Interferon-alpha*
Measles
Measles virus
Subacute Sclerosing Panencephalitis*
Young Adult
Antibodies
Hemagglutinins
Inosine Pranobex
Interferon-alpha
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