J Korean Neuropsychiatr Assoc.
2010 Nov;49(6):564-569.
Korean Medication Algorithm Project for Generalized Anxiety Disorder 2009 (III) : Treatment Strategy for Comorbid Conditions
- Affiliations
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- 1Department of Psychiatry, School of Medicine, CHA University, Seoul, Korea.
- 2Department of Psychiatry, Chonbuk National University Medical School, Jeonju, Korea. yangjc@jbnu.ac.kr
- 3Department of Psychiatry, Inje University College of Medicine, Seoul, Korea.
- 4Department of Psychiatry, Yonsei University College of Medicine, Seoul, Korea.
- 5Department of Psychiatry, Sungkyunkwan University College of Medicine, Seoul, Korea.
Abstract
OBJECTIVES
This study investigated the consensus about treatment strategies for comorbid conditions in generalized anxiety disorder (GAD).
METHODS
The executive committee of the Korean Medication Algorithm Project for GAD developed questionnaires about treatment strategies for patients with panic disorder based on guidelines or algorithms and clinical trial studies previously published in foreign countries. This study analyzed the treatment strategies for comorbid conditions in GAD. Fifty-five (65%) of 84 experts on a committee reviewing GADs responded to the questionnaires. We classified the consensus of expert opinions into three categories (first-line, second-line, and third-line treatment strategies) and identified the treatment of choice according using a chi2 test and 95% confidence interval.
RESULTS
The consensus about treatment strategies in the case of GAD with comorbid depression recommended a selective serotonin reuptake inhibitor (SSRI) and a serotonin norepinephrine reuptake inhibitor (SNRI) as the first-line drug treatment. An SSRI, an SNRI and a benzodiazepine (e.g. alprazolam, clonazepam) are recommended in GAD patients with other comorbid anxiety disorders.
CONCLUSION
This study provided information about the consensus among Korean experts with regard to treatment strategies for comorbid conditions of GAD.
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