J Korean Neuropsychiatr Assoc.  2004 Jul;43(4):381-385.

Monocyte Chemoattractant Protein-1(MCP1)-2518 Polymorphism and Major Depressive Disorder

• Pae CU
• Lee JH
• Shin YK
• Kim TS
• Kim JJ
• Lee CU
• Lee SJ
• Jun TY
• Lee C
• Paik IH

Abstract

OBJECT: This study was designed to examine the association between monocyte chemoattractant protein-1 (MCP1) -2518 polymorphism and major depressive disorder (MDD).
METHODS
Ninety patients with MDD and 114 healthy controls participated in this study. Genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism method.
RESULTS
Genotype and allele distributions in patients with MDD were significantly different from those of the controls. In particular, subjects with the allele A were found to have an increased risk of MDD.
CONCLUSION
The present study suggests that the MCP1 -2518 polymorphism may have a potential role for susceptibility to MDD in the Korean population and thus calls for consecutive studies in order to pile up the data with larger different ethnic background.

Keyword

Major depressive disorder; MCP1 -2518 polymorphism; Korean

MeSH Terms

Alleles
Chemokine CCL2
Depressive Disorder, Major*
Genotype
Humans
Monocytes*
Chemokine CCL2