J Korean Neuropsychiatr Assoc.  2004 Sep;43(5):524-528.

Monocyte Chemoattractant Protein-1(MCP1) -2518 Polymorphism and Bipolar I Disorder

• Pae CU
• Kim TS
• Jang WY
• Kim JJ
• Lee CU
• Lee SJ
• Jun TY
• Lee C
• Paik IH

Abstract

OBJECTIVES
Several studies suggested that cytokines could be involved in the pathogenesis of mood disorders, while data for bipolar disorder is relatively deficient (BD). BD, Knowned to have a inherited tendency, has been considered to be related with T-helper cell system. This study was designed to investigate the association between polymorphism of monocyte chemoattractant protein-1 (MCP1) gene at promoter -2518 and BD.
METHODS
Patients with BD (n=92) in accordance with DSM-IV criteria and control subjects (n=114) participated in this study. DNA was extracted from whole blood and the MCP-1 gene promoter region was amplified by polymerase chain reaction-based method.
RESULTS
Genotype and allele distributions in patients with BD were not different from those of control subjects (p=0.587; p=0.384). Genotype and allele distributions in accordance to presence or absence of suicide attempt (p=0.423), family history (p=0.733) and psychotic feature (p=0.436) were not different between the two groups.
CONCLUSION
Present study suggests that the MCP1 promoter -2518 polymorphism may not affect the susceptibility and clinical diversity of the development of BD.

Keyword

Bipolar disorder; MCP1 promoter -2518 polymorphism

MeSH Terms

Alleles
Bipolar Disorder
Chemokine CCL2
Cytokines
Diagnostic and Statistical Manual of Mental Disorders
DNA
Genotype
Humans
Monocytes*
Mood Disorders
Promoter Regions, Genetic
Suicide
Chemokine CCL2
Cytokines
DNA