J Korean Neuropsychiatr Assoc.
1998 Nov;37(6):1317-1324.
Effects of Polygalae Radix on Apomorphine-Induced Stereotyped Behaviors in Mice
- Affiliations
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- 1Department of Neuropsychiatry, College of Medicine, Chungbuk National University, Cheongju, Korea.
- 2Department of Microbiology, Institute of Biotechnology, Daejun, Korea.
- 3Department of Biochemistry, College of Medicine, Seoul National University, Seoul, Korea.
- 4Department of Psychiatry, College of Medicine, Seoul National University, Seoul, Korea.
Abstract
OBJECTIVES
This study was to investigate in vivo activities of Polygalae Radix, a natural plant including active components having affinities to central nervous system receptors, using an animal model for psychotic disorders in terms of behavioral psychopharmacology.
METHODS
The extracts of Polygalae Radix in two concentrations of 5.0mg/g and 0..5mg/g were administered to mice in order to explore the suppression of apomorphine-induced stereotyped behaviors visually and to compare with the effects of haloperidol and control. 10 mice were tested in each groups.
RESULTS
The capacities of suppressing the apomorphine-induced stereotyped behaviors were observed in decreasing order of haloperidol, Polygalae Radix 5.0mg/g, Polygalae Radix 0..5mg/g and control. The extracts of Polygalae Radix in both concentrations suppressed apomorphine- induced stereotyped behaviors significantly, and Polygalae Radix 5.0mg/g was as potent as haloperidol.
CONCLUSION
This suggests that Polygalae Radix contain some effective ingredients to influence the central dopamine pathway in vivo. The identification of the chemical structures and the exploration of the biochemical and pharmacological characteristics of active components are to be required through further studies.
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