Korean J Psychopharmacol.
2000 Sep;11(3):254-261.
The Effect of Polygalasaponins in Polygalae Tenuifolia on Apomorphine-Induced Hyperlocomotions in Mice
- Affiliations
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- 1Department of Neuropsychiatry, College of Medicine, Chungbuk National University, Cheongju, Korea.
- 2Anticancer Agent Research Lab., Korea Research Institute of Bioscience and Biotechnology (KRIBB) Taejun, Korea.
- 3Department of Psychiatry, College of Medicine, Seoul National University, Seoul, Korea. KYS@snu.ac.kr
- 4Department of Biochemistry and Molecular Biology, School of Medicine, Sungkyunkwan University, Suwon, Korea.
- 5 Hanbit Neuropsychiatric Clinic, Jeju, Korea.
Abstract
OBJECTIVE
This study was to investigate in vivo antidopaminergic activities of polygalasaponins which included in the roots of Polygalae tenuifolia, one of the natural plants prescribed to treat psychotic disorders in traditional medicine.
METHODS
The chemical separations were conducted by chromatographies with various columns and the chemical structures were identified using spectroscopy, NMR and so on. The apomorphine-induced stereotyped behaviors and climbing behaviors in mice as animal models of psychotic disorders were applied to explore the antidopaminergic activity.
RESULTS
The active compounds with antidopaminergic effects in the roots of Polygalae tenuifolia were identified as polygalasaponin A-D. The polygalasaponins showed to suppress the apomorphine-induced stereotyped behaviors and climbing behaviors in dose-related fashions.
CONCLUSION
This study suggests that polygalasaponins might have antipsychotic activities. The natural products need to be explored extensively as sources of new medications in psychiatric fields. Further explorations for chemical and pharmacological properties of polygalasaponins are required.
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