Eradication Rate for Helicobacter Pylori in the Elderly

Park, Ju Sang; Hong, Seon Seon; Lee, Young Soo; Lee, Eunju; Myung, Seung Jae; Jung, Hwoon Yong; Yang, Suk Kyun

Abstract

BACKGROUND: Helicobacter Pylori(H.pylori) causes chronoc gastritis and petric ulcer and is related to the development of stomach cancer. Proton pump inhibitor(PPI)-based new triple regimens are widely used at present to eradicate H.pylori. However, it still remains unclear whether these regimens are also effective in the elderly.
METHODS
H. pylori was determined by CLO test and/or histology. The effectiveness of 1-wk new triple therapy(OMC25 or OMC5; Omeprazole 20 mg b.d., clarithromycin 250 mg or 500 mg b.d., and metronidazole 500 mg b.d., OAC; omeprazole 20 mg b.d., clarithromycin 500 mg b.d., and amoxicillin 10 g b.d.) on the eradication of H.pylori was evaluated in 1,042 patients with peptic ulcer or non-ulcer dyspepsia(NUD) in a retrospective study. We also prospectively investigated the eradication rate of quadruple therapy(omeprazole, tripotassium dicitrato bismuthate, amoxicillin and tetracycline) for 10 days in 150 pa-tients who failed the eradication by the new triple therapy.
RESULTS
The overall eradication rate of the new triple therapy was 86.9% with those of OMC25, OMC5 and OAC being 76.6, 87.7 and 88.7%, respectively. The eradication rate of OMC25 was lower than that of OMC5 and OAC(p<0.005). The eradication rate of quadruple therapy was 64.7%. No significant difference in eradication rates was observed between the elderly and young persons, male and female, and underlying diseases.
CONCLUSION
The similar eradication rate of the new triple therapy and quadruple therapy between the elderly and young persons suggests that these regimens are also recommendable for the eradication of H.pylori in the elderly.