Korean J Med.  2021 Feb;96(1):13-21. 10.3904/kjm.2021.96.1.13.

The Current Strategy of Helicobacter pylori Eradication

Affiliations
  • 1Department of Internal Medicine, Kyungpook National University Chilgok Hospital, Kyungpook National University School of Medicine, Daegu, Korea

Abstract

Helicobacter pylori (H. pylori) is the main cause of most gastroduodenal diseases. Triple therapy including two antibiotics, amoxicillin and clarithromycin, and a proton pump inhibitor given for a week has been recommended as the treatment of choice since the revision of the Korean H. pylori Clinical Practice Guidelines in 2013. However, antimicrobial resistance significantly decreased the cure rate of H. pylori eradication to 63.9%. Thus, the new H. pylori treatment regimen would be needed to increase the eradication rate in Korea. Recently, the update of clinical practice guideline for treatment of H. pylori was developed by conducting a meta-analysis. In this review, the recommended H. pylori eradication regimen in current 2020 guideline will be discussed.

Keyword

Helicobacter pylori; Drug resistance; Clarithromycin; Metronidazole; 헬리코박터 파일로리; 약제내성; 클래리스로마이신; 메트로니다졸
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