J Korean Ophthalmol Soc.  1999 Jan;40(1):70-74.

Immunohistochemical Study of PCNA(Proliferating Cell Nuclear Antigen) in Pterygium

• Min JB
• Choi YS
• Kim JY

Abstract

To investigate cellular proliferation pattern of pterygial tissue, eleven paraffin sections through two normal conjunctiva, six primary and three recurrent pterygia were studied immunohistochemically by finding epithelial cells and subepithelial fibroblasts staining patterns as defined by monoclonal antibody for proliferating cell nuclear antigen(PCNA). The results showed similar epithelial cellular proliferation patterns in normal conjunctiva, primary and recurrent pterygia. But scattered patches of fibroblasts in subepithelial connective tissue staining positive with PCNA were found only in recurrent pterygium. Our results suggest that primary pterygium is not a disorder of excess cellular proliferation, but a proliferation of fibroblasts in subepithelial connective tissue have a role in pathogenesis of recurrent pterygium.

Keyword

Cellular proliferation; Epithelium; Fibroblast; Proliferating cell nuclear antigen; Pterygium

MeSH Terms

Cell Proliferation
Conjunctiva
Connective Tissue
Epithelial Cells
Epithelium
Fibroblasts
Paraffin
Proliferating Cell Nuclear Antigen
Pterygium*
Paraffin
Proliferating Cell Nuclear Antigen