J Korean Pediatr Soc.  1998 Aug;41(8):1149-1152.

A Case of Systemic Lupus Erythematosus (SLE) with Antiphospholipid Antibodies Presented with Tendency for Severe Bleeding

• Chang MS
• Kim MA
• Dong ES
• Ahn YM
• Choi Y

Abstract

We report a case of SLE with antiphospholipid antibodies presented initially with severe bleeding. A six-year-old boy was admitted due to severe nasal bleeding for 2 months. The boy showed typical malar rash. The laboratory tests indicated that his platelet count was 80,000/mm3 and the PT and the aPTT were markedly prolonged. A number of clotting factors were decreased, including factorsll<12%, Vll: 42%, lX : 38%, Xl: 41%, and Xll: 16%. Urinalysis showed hematuria and proteinuria, and 24-hour urine protein was 1.37g/day. Venereal Disease Research Laboratory (VDRL) test was false positive, Coombs test, lupus anticoagulants and anticardiolipin antibodies (IgG and IgM) were positive. His symptoms and laboratory tests fulfilled the criteria of SLE with antiphospholipid antibody. Renal pathology showed lupus nepritis (diffuse proliferative glomerulonephritis, class lV). After steroid therapy, his nasal bleeding stopped immediately, and laboratory findings became normalized. This case showed the tendency of paradoxic bleeding, instead of the expected thrombosis which can be found in this type of patient. We anticipate it is mainly due to pronounced prothrombin deficiency.

Keyword

Systemic lupus erythematosus; Antiphospholipid antibody; Bleeding; Hypoprothrom binemia

MeSH Terms

Antibodies, Anticardiolipin
Antibodies, Antiphospholipid*
Anticoagulants
Coombs Test
Epistaxis
Exanthema
Glomerulonephritis
Hematuria
Hemorrhage*
Humans
Hypoprothrombinemias
Lupus Erythematosus, Systemic*
Male
Pathology
Platelet Count
Proteinuria
Sexually Transmitted Diseases
Thrombosis
Urinalysis
Antibodies, Anticardiolipin
Antibodies, Antiphospholipid
Anticoagulants