Osteoporos Sarcopenia.  2016 Jun;2(2):65-76. 10.1016/j.afos.2016.05.002.

Bidirectional ephrin signaling in bone

• Rundle CH
• Xing W
• Lau KH
• Mohan S

• KMID: 2328922
• DOI: http://doi.org/10.1016/j.afos.2016.05.002

Abstract

The interaction between ephrin ligands (efn) and their receptors (Eph) is capable of inducing forward signaling, from ligand to receptor, as well as reverse signaling, from receptor to ligand. The ephrins are widely expressed in many tissues, where they mediate cell migration and adherence, properties that make the efn-Eph signaling critically important in establishing and maintaining tissue boundaries. The efn-Eph system has also received considerable attention in skeletal tissues, as ligand and receptor combinations are predicted to mediate interactions between the different types of cells that regulate bone development and homeostasis. This review summarizes our current understanding of efn-Eph signaling with a particular focus on the expression and functions of ephrins and their receptors in bone.

Keyword

Ephrins; Signaling; Bone; Osteoblast; Osteoclast

MeSH Terms

Bone Development
Cell Movement
Ephrins
Homeostasis
Ligands
Osteoblasts
Osteoclasts
Ephrins
Ligands