- Molecular mechanisms of hederagenin in bone formation
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Seo HJ, Kwun IS, Kwon J, Sim Y, Cho YE
- KMID: 2537839
- J Nutr Health.
- 2022 Dec;55(6):617-629.
- doi: 10.4163/jnh.2022.55.6.617
Purpose: Osteoporosis is characterized by structural deterioration of the bone tissue because of the loss of osteoblastic activity or the increase in osteoclastic activity, resulting in bone fragility and an... -
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- The Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Pathway in Osteoblasts
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Greenblatt MB, Shim JH, Bok S, Kim JM
- KMID: 2527582
- J Bone Metab.
- 2022 Feb;29(1):1-15.
- doi: 10.11005/jbm.2022.29.1.1
Extracellular signal-regulated kinases (ERKs) are evolutionarily ancient signal transducers of the mitogen-activated protein kinase (MAPK) family that have long been linked to the regulation of osteoblast differentiation and bone formation.... -
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- Effect of Urolithin A on Bone Repair in Mice with Bone Defects
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Liu J, Ma L, Dong W, Du G, Dang X
- KMID: 2525414
- Tissue Eng Regen Med.
- 2022 Feb;19(1):151-159.
- doi: 10.1007/s13770-021-00382-9
BACKGROUND: Bone defect difficult to manage clinically and it is a big challenge to repair it. Secondary metabolites source from herb has shown potential for the treatment of bone defect. METHODS:... -
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- Effects of the Lysine Methyltransferase Inhibitor AZ505 on Bone Metabolism
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Song MK, Jung S, Hong S, Kwon JO, Kim MK, Kim HH
- KMID: 2523248
- J Bone Metab.
- 2021 Nov;28(4):297-305.
- doi: 10.11005/jbm.2021.28.4.297
Background: Protein methylation has important role in regulating diverse cellular responses, including differentiation, by affecting protein activity, stability, and interactions. AZ505 is an inhibitor of the SET and MYND domain-containing... -
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- Aqueous extract of Petasites japonicus leaves promotes osteoblast differentiation via up-regulation of Runx2 and Osterix in MC3T3-E1 cells
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Kim EJ, Jung JI, Jeon YE, Lee HS
- KMID: 2520660
- Nutr Res Pract.
- 2021 Oct;15(5):579-590.
- doi: 10.4162/nrp.2021.15.5.579
BACKGROUND/OBJECTIVES: Petasites japonicus Maxim (P. japonicus) has been used as an edible and medicinal plant and contains many bioactive compounds. The purpose of this study is to investigate the effect... -
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- Effects of Advanced Glycation End Products on Differentiation and Function of Osteoblasts and Osteoclasts
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Park SY, Choi KH, Jun JE, Chung HY
- KMID: 2520365
- J Korean Med Sci.
- 2021 Sep;36(37):e239.
- doi: 10.3346/jkms.2021.36.e239
Background: Risk of fragility fractures increases in patients with diabetes mellitus, independent of bone mineral density. In the present study, the effects of advanced glycation end products (AGEs) on differentiation... -
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- Anti-Müllerian Hormone Negatively Regulates Osteoclast Differentiation by Suppressing the Receptor Activator of Nuclear Factor-κB Ligand Pathway
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Kim JH, Yang YR, Kwon KS, Kim N
- KMID: 2520183
- J Bone Metab.
- 2021 Aug;28(3):223-230.
- doi: 10.11005/jbm.2021.28.3.223
Background: Multiple members of the transforming growth factor-β (TGF-β) superfamily have well-established roles in bone homeostasis. Anti-Müllerian hormone (AMH) is a member of TGF-β superfamily of glycoproteins that is responsible... -
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- Osteogenic Response of MC3T3-E1 and Raw264.7 in the 3DEncapsulated Co-Culture Environment
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Kim J, Lyu HZ, Jung C, Lee KM, Han SH, Lee JH, Cha M
- KMID: 2516526
- Tissue Eng Regen Med.
- 2021 Jun;18(3):387-397.
- doi: 10.1007/s13770-020-00321-0
BACKGROUND: Three-dimensional (3D) in vitro cultures recapitulate the physiological microenvironment and exhibit high concordance with in vivo conditions. Improving co-culture models with different kind of cell types cultured on a... -
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- Carnosol induces the osteogenic differentiation of bone marrowderived mesenchymal stem cells via activating BMP-signaling pathway
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Abdallah BM
- KMID: 2514945
- Korean J Physiol Pharmacol.
- 2021 May;25(3):197-206.
- doi: 10.4196/kjpp.2021.25.3.197
Carnosol is a phenolic diterpene phytochemical found in rosemary and sage with reported anti-microbial, anti-oxidant, anti-inflammatory, and anti-carcinogenic activities. This study aimed to investigate the effect of carnosol on the... -
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- High concentration of calcium represses osteoblast differentiation in C2C12 cells
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Lee YJ, Han Y
- KMID: 2510196
- Int J Oral Biol.
- 2020 Dec;45(4):162-168.
- doi: 10.11620/IJOB.2020.45.4.162
Calcium is the most abundant stored mineral in the human body and is especially vital for bone health; thus, calcium deficiency can cause bone-related diseases, such as osteopenia and osteoporosis.... -
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- Zinc modulation of osterix in MC3T3-E1 cells
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Seo HJ, Jeong JB, Cho YE, Kwun IS
- KMID: 2506197
- J Nutr Health.
- 2020 Aug;53(4):347-355.
- doi: 10.4163/jnh.2020.53.4.347
Purpose: Zinc is known to be associated with osteoblast proliferation and differentiation. Osterix as zinc-finger transcription factor is also related to osteoblast differentiation and bone formation. In the present study, we... -
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- Osteoblast-Based Therapy—A New Approach for Bone Repair in Osteoporosis: Pre-Clinical Setting
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Mahmoud NS, Mohamed MR, Ali MAM, Aglan HA, Amr KS, Ahmed HH
- KMID: 2502560
- Tissue Eng Regen Med.
- 2020 Jun;17(3):363-373.
- doi: 10.1007/s13770-020-00249-5
BACKGROUND: Osteoporosis is a metabolic bone disease characterized by low bone density resulting in increased fracture susceptibility. This research was constructed to uncover the potential therapeutic application of osteoblasts transplantation,... -
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- Bone Cell Communication Factors Provide a New Therapeutic Strategy for Osteoporosis
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Kim JH, Kim N
- KMID: 2500831
- Chonnam Med J.
- 2020 May;56(2):94-98.
- doi: 10.4068/cmj.2020.56.2.94
Bone homeostasis is strictly regulated by the balance between bone resorption by osteoclasts and bone formation by osteoblasts. Many studies have shown that osteoclasts affect osteoblasts, and vice versa, through... -
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- Freeze-Dried Platelet-Rich Plasma Induces Osteoblast Proliferation via Platelet-Derived Growth Factor Receptor-Mediated Signal Transduction
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Kinoshita , Orita S, Inage K, Fujimoto K, Shiga Y, Abe K, Inoue M, Norimoto M, Umimura T, Ishii T, Yonemoto T, Kamoda H, Tsukanishi T, Suzuki M, Hirosawa N, Akazawa T, Ohtori S
- KMID: 2501180
- Asian Spine J.
- 2020 Jan;14(1):1-8.
- doi: 10.31616/asj.2019.0048
Study Design: Controlled laboratory study. Purpose: This study aimed to evaluate the in vitro pharmacological activity of growth factors (GFs) in freeze-dried platelet-rich plasma (FD-PRP) after storage for 4 weeks. Overview of... -
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- Protective Effects of Ursolic Acid on Osteoblastic Differentiation via Activation of IER3/Nrf2
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Lee SI
- KMID: 2460998
- J Dent Hyg Sci.
- 2019 Sep;19(3):198-204.
- doi: 10.17135/jdhs.2019.19.3.198
BACKGROUND: Oxidative stress is a known to be associated with in the pathogenesis of many inflammatory diseases, including periodontitis. Ursolic acid is a pentacyclic triterpenoid with has antimicrobial, antioxidative, and... -
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- Stimulatory Effects of KPR-A148 on Osteoblast Differentiation and Bone Regeneration
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Lim S, Kim JA, Lee T, Lee D, Nam SH, Lim J, Park EK
- KMID: 2455049
- Tissue Eng Regen Med.
- 2019 Aug;16(4):405-413.
- doi: 10.1007/s13770-019-00200-3
BACKGROUND: Xanthine derivatives have been used to treat a variety of medical conditions including respiratory disease and neural degeneration. However, few studies have reported their effects on bone regeneration. Therefore,... -
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- Silencing of LncRNA-ANCR Promotes the Osteogenesis of Osteoblast Cells in Postmenopausal Osteoporosis via Targeting EZH2 and RUNX2
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Cai N, Li C, Wang F
- KMID: 2452956
- Yonsei Med J.
- 2019 Aug;60(8):751-759.
- doi: 10.3349/ymj.2019.60.8.751
PURPOSE: This study aimed to explore the effects and mechanisms of long non-coding RNA (lncRNA) anti-differentiation non-coding RNA (ANCR) on the osteogenesis of osteoblast cells in postmenopausal osteoporosis (PMOP). MATERIALS AND... -
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- Effects of the cathepsin K inhibitor with mineral trioxide aggregate cements on osteoclastic activity
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Kim HS, Kim S, Ko H, Song M, Kim M
- KMID: 2446665
- Restor Dent Endod.
- 2019 May;44(2):e17.
- doi: 10.5395/rde.2019.44.e17
OBJECTIVES: Root resorption is an unexpected complication after replantation procedures. Combining anti-osteoclastic medicaments with retrograde root filling materials may avert this resorptive activity. The purpose of this study was to... -
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- Conditioned Medium Enhances Osteogenic Differentiation of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells
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Zhong S, He X, Li Y, Lou X
- KMID: 2449245
- Tissue Eng Regen Med.
- 2019 Apr;16(2):141-150.
- doi: 10.1007/s13770-018-0173-3
BACKGROUND: Recent studies have shown that induced pluripotent stem cells (iPSCs) could be differentiated into mesenchymal stem cells (MSCs) with notable advantages over iPSCs per se. In order to promote... -
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- Remifentanil promotes osteoblastogenesis by upregulating Runx2/osterix expression in preosteoblastic C2C12 cells
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Yoon JY, Kim TS, Ahn JH, Yoon JU, Kim HJ, Kim EJ
- KMID: 2444753
- J Dent Anesth Pain Med.
- 2019 Apr;19(2):91-99.
- doi: 10.17245/jdapm.2019.19.2.91
BACKGROUND: The imbalance between osteoblasts and osteoclasts can lead to pathological conditions such as osteoporosis. It has been reported that opioid adversely affect the skeletal system, but it is inconsistent.... -
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