J Korean Assoc Oral Maxillofac Surg.  2006 Aug;32(4):360-373.

The effect of pulsed electromagnetic fields on beta-TCP graft in rabbit cranial bone defect

• Kim SW
• Hwang KG
• Lim BS
• Park CJ
• Chung IH
• Paik SS
• Shim KS

Abstract

The purpose of this research was to investigate whether pulsed electromagnetic field (PEMF) stimulation applied to the rabbit cranial defects grafted with beta-tricalcium phosphate (beta-TCP) could affect the new bone formation. With 16 New Zealand white rabbits under the same condition, bilateral calvarial bone defects were formed around the sagittal suture line. The defect on the left side was grafted with beta-TCP, while on the right side was grafted by harvested autogenous bone. PEMF was applied to 8 rabbits for 8 hours per day. The bony specimen were divided into 3 groups, the group 1 was autogenous bone grafted specimen, the group 2 was beta-TCP grafted with PEMF, and the group 3 was beta-TCP grafted without PEMF. We investigated the bone regeneration and growth factor expression at 2, 4, 6, and 8 weeks. As a result, BMP 2 was expressed in the group 1 from 2 weeks, the group 2 from 4 weeks, and the group 3 from 6 weeks. BMP 4 was expressed in the group 1 from 2 weeks, in the group 2 and the group 3 from 4 weeks. 4. There was no significant difference in expression pattern of BMP 7, PDGF, VEGF, and TGF-beta1 during grafted bone regeneration in group 1, 2, and 3. According to our results, PEMF stimulation could be effective on the new bome formation in animal study, and have a feasibility of clinical use.

Keyword

Pulsed electromagnetic field (PEMF); Autogenous bone; beta-tricalcium phosphate (beta-TCP); Osteogenesis

MeSH Terms

Animals
Bone Regeneration
Electromagnetic Fields*
Magnets*
Osteogenesis
Rabbits
Sutures
Transforming Growth Factor beta1
Transplants*
Vascular Endothelial Growth Factor A
Transforming Growth Factor beta1
Vascular Endothelial Growth Factor A