Exp Mol Med.
2016 Jan;48(1):e201. 10.1038/emm.2015.93.
The role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistance
- Affiliations
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- 1Department of Molecular Medicine, School of Medicine, Gachon University, Incheon, Korea. msyoon@gachon.ac.kr
- 2Korea Mouse Metabolic Phenotyping Center (KMMPC), Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Korea.
- 3Department of Endocrinology, Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea.
- KMID: 2327670
- DOI: http://doi.org/10.1038/emm.2015.93
Abstract
- Mammalian target of rapamycin (mTOR) controls cell growth and metabolism in response to nutrients, energy, and growth factors. Recent findings have placed the lysosome at the core of mTOR complex 1 (mTORC1) regulation by amino acids. Two parallel pathways, Rag GTPase-Ragulator and Vps34-phospholipase D1 (PLD1), regulate mTOR activation on the lysosome. This review describes the recent advances in understanding amino acid-induced mTOR signaling with a particular focus on the role of mTOR in insulin resistance.
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