J Nutr Health.  2013 Dec;46(6):511-520.

Association of MCP-1 polymorphism with cardiovascular disease risk factors in Korean elderly

• Park HJ

Abstract

Monocyte chemoattractant protein-1 (MCP-1) plays an important role in cardiovascular disease (CVD). Genetic polymorphism in the regulatory regions of MCP-1 could affect MCP-1 expression. The purpose of the study was to explore the possible association of MCP-1 -2518 A/G genetic polymorphism and CVD risk factors in the elderly Korean population. Dietary, anthropometric, and biochemical factors were assessed in 168 subjects. The frequency of A/A, G/A, and G/G genotypes was 14.2%, 45.8%, and 40.0%, respectively. The blood level of MCP-1 was significantly higher in subjects with A/A genotype. The MCP-1 level was significantly higher in A/A genotype with hypercholesterolemia than in other genotypes. Meat intake and percent energy from lipids were significantly positively correlated with the MCP-1 level, especially, stronger in A/A genotype. In the stepwise discriminant analysis, TNF-alpha level, meat intake, HDL-C were associated with MCP-1 in all subjects (model R2 = 24%). TNF-alpha level, sugar intake, cholesterol intake, and meat intake affected MCP-1 in A/A genotype (model R2 = 82%), but not in G/A or G/G. In conclusion, subjects possessing A/A genotype exhibited higher levels of MCP-1 than other genotypes in Korean elders. Further, meat, sugar, and cholesterol intakes affected the MCP-1 level. Therefore, the decrement of meat, sugar, and cholesterol intakes helps to normalize the MCP-1 level and can decrease CVD risk in A/A genotype.

Keyword

MCP-1; MCP-1 polymorphism; dietary factors; Korean elders

MeSH Terms

Aged*
Cardiovascular Diseases*
Chemokine CCL2
Cholesterol
Genotype
Humans
Hypercholesterolemia
Meat
Polymorphism, Genetic
Regulatory Sequences, Nucleic Acid
Risk Factors*
Tumor Necrosis Factor-alpha
Chemokine CCL2
Cholesterol
Tumor Necrosis Factor-alpha

Figure

• 

  Fig. 1. The level of MCP-1 according to genotype in the subject with dyslipideamia and obese. ab: Different superscript letters indicate the comparison with significant differences according to MCP-1 genotypes within the same category by GLM test at p ＜ 0.05.

• 

  Fig. 2. The plasma MCP-1 level according to intake of meat (A), sugar (B), % energy from carbohydrate (C), % energy from lipid (D) by genotype. ab: Different superscript letters indicate the comparison with significant differences according to MCP-1 genotypes within the same category by GLM test at p ＜ 0.05. *: Significant differences according to intake levels within the same genotypes by Student's t-test, p ＜ 0.05.

Reference

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