J Korean Acad Rehabil Med.  2010 Aug;34(4):381-386.

Effect of Stimulation Intensity and Location of Cerebral Infarction on Motor Evoked Potentials in the Rat

Affiliations
  • 1Department of Rehabilitation Medicine, Dankook University College of Medicine, Korea. rmlee@dankook.ac.kr
  • 2Department of Anatomy, Dankook University College of Medicine, Korea.

Abstract


OBJECTIVE
To investigate the change of motor evoked potential (MEP) in the cerebral infarction, and observe the effect of stimulation intensity and location of cerebral infarction, using rat model of cerebral ischemia induced by endothelin-1 (ET-1). METHOD: Middle cerebral artery (MCA) infarct, cortical infarct, and internal capsular infarct were induced in Spraugue-Dawley rats, by injecting ET-1 stereotaxically. MEP was recorded in forelimb by transcranial magnetic stimulation at 100%, 120%, and 150% of motor threshold by a small figure-8 coil. The location of cerebral infarction was confirmed histologically by 2,3,5-triphenyltetrazolium chloride (TTC) staining.
RESULTS
In MCA infarct, MEP was not recorded at all intensity. In internal capsular infarct, no MEP was recorded at 100% of motor threshold, and amplitude was decreased at 120%. In cortical infarct, MEP was not recorded at 100%, but amplitude was maintained at 120% and 150%. Latency did not change significantly at all intensity.
CONCLUSION
Amplitude of MEP decreased after cerebral infarction, but latency did not change. Decrease in amplitude was larger with deeper location of cerebral infarction. Cerebral cortex was stimulated at 100% of motor threshold, subcortical structure was stimulated at 120%, and deeper structure was stimulated at 150%, respectively.

Keyword

Motor evoked potentials; Cerebral ischemia; Endothelin-1; Rat

MeSH Terms

Animals
Brain Ischemia
Cerebral Cortex
Cerebral Infarction
Endothelin-1
Evoked Potentials, Motor
Forelimb
Middle Cerebral Artery
Rats
Tetrazolium Salts
Transcranial Magnetic Stimulation
Endothelin-1
Tetrazolium Salts
Full Text Links
  • JKARM
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr