J Neurogastroenterol Motil.  2012 Apr;18(2):174-180.

The Therapeutic and Diagnostic Value of 2-week High Dose Proton Pump Inhibitor Treatment in Overlapping Non-erosive Gastroesophageal Reflux Disease and Functional Dyspepsia Patients

• Kriengkirakul C
• Patcharatrakul T
• Gonlachanvit S

Abstract

BACKGROUND/AIMS
To evaluate the value of a 2-week high dose proton pump inhibitor (PPI) treatment on patients with overlapping non-erosive gastroesophageal reflux disease (NERD) and functional dyspepsia (FD).
METHODS
Sixty overlapping NERD and FD patients with symptom onset > 3 months prior underwent 24-hour esophageal pH monitoring studies. All patients received rabeprazole 20 mg b.i.d. for 2 weeks. The reflux and dyspeptic symptoms were evaluated using a symptom questionnaire with 4-point Likert scales before and at the end of treatment. A positive PPI test was defined as score improvement in > or = 50% from the baseline in the typical reflux symptoms.
RESULTS
The prevalence of each reflux and dyspeptic symptom did not differ significantly between patients with positive and negative pH tests. After the PPI treatment, epigastric burning, acid regurgitation, heartburn, nausea, vomiting and chest discomfort scores were significantly improved compared to pretreatment values (P < 0.05), whereas postprandial abdominal fullness, early satiation, belching and food regurgitation were not. The proportion of patients who responded to the PPI treatment did not differ significantly between patients with positive and negative pH tests. The sensitivity, specificity, PPV, NPV and accuracy of 2-week high dose rabeprazole treatment for diagnosing gastroesophageal reflux disease were 47%, 38%, 50%, 35% and 43%, respectively.
CONCLUSIONS
The two-week high dose PPI treatment was not effective for early satiation, postprandial abdominal fullness, regurgitation or belching symptoms in patients with overlapping NERD and FD. Acid exposure in the distal esophagus could not predict the response of symptoms to PPI. In addition, the 2-week PPI test provided limited value for gastroesophageal reflux disease diagnosis in patients with overlapping NERD and FD.

Keyword

Diagnosis; Dyspepsia; Gastroesophageal reflux; Proton pump inhibitors; Therapeutics

MeSH Terms

2-Pyridinylmethylsulfinylbenzimidazoles
Burns
Dyspepsia
Eructation
Esophageal pH Monitoring
Esophagus
Gastroesophageal Reflux
Heartburn
Humans
Hydrogen-Ion Concentration
Nausea
Prevalence
Proton Pump Inhibitors
Proton Pumps
Protons
Surveys and Questionnaires
Satiation
Sensitivity and Specificity
Thorax
Vomiting
Weights and Measures
2-Pyridinylmethylsulfinylbenzimidazoles
Proton Pump Inhibitors
Proton Pumps
Protons