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Efficacy and Safety of AlbisD Compared With Omeprazole 20 mg in Patients With Non-erosive Reflux Disease: A Randomized, Open-label, Active-controlled, Pilot Study

Kim EJ, Lee OY, Lee KN, Lee SJ, Jang JY, Cho JW, Kim TO

  • KMID: 2454639
  • J Neurogastroenterol Motil.
  • 2019 Jul;25(3):403-412.
  • doi: 10.5056/jnm18185
BACKGROUND/AIMS: Proton pump inhibitors (PPIs) are frequently used to treat non-erosive reflux disease (NERD), but their effect is limited. It is not known whether a potential alternative, AlbisD, containing ranitidine...
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Multicenter Prospective Study of Laparoscopic Nissen Fundoplication for Gastroesophageal Reflux Disease in Korea

Park S, Park JM, Kim JJ, Lee IS, Han SU, Seo KW, Kwon JW

  • KMID: 2454638
  • J Neurogastroenterol Motil.
  • 2019 Jul;25(3):394-402.
  • doi: 10.5056/jnm19059
BACKGROUNDS/AIMS: This multicenter study aims to evaluate the effect and feasibility of anti-reflux surgery compared with medical treatment for gastroesophageal reflux disease (GERD). METHODS: Patients with GERD who were undergoing medical...
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The Gastroesophageal Reflux Disease Questionnaire in Adolescents: What Is the Best Cutoff Score?

Artanti D, Hegar B, Kaswandani N, Soedjatmiko , Prayitno A, Devaera Y, Vandenplas Y

BACKGROUND: A self-assessment questionnaire, the GERD-Questionnaire (GERD-Q) was used to determine the prevalence of GERD in adolescents, describe the related factors, and determine the impact on quality of life (QoL). METHODS:...
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Thoracic Splenosis after Splenic and Diaphragmatic Injury

Ha YJ, Hong TH, Choi YS

Thoracic splenosis is a rare disease that develops as a result of autotransplantation of splenic tissue into the thoracic cavity following splenic and diaphragmatic injury. We report the case of...
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The Clinical Efficacy of a Pure Alginate Formulation (Lamina G) for Controlling Symptoms in Individuals with Reflux Symptoms: A Randomized Clinical Study

Kim JH, Lee YC, Kim EH, Park JC, Shin SK, Lee SK, Jung DH, Park JJ, Youn YH, Park H

BACKGROUND/AIMS: Bicarbonate-containing alginate formulations are reported to be effective for controlling reflux symptoms. However, the efficacy of Lamina G alginate without gas production has not been reported. The aim is...
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Cough related to swallowing in asthma patients

Kamimura M, Mouri A, Takayama K, Mizutani T, Hamamoto Y, Iikura M, Furihata K

BACKGROUND: Occurrence of cough during swallowing is common among asthma patients, but has not been investigated in detail. OBJECTIVE: We conducted an observational study to determine the prevalence of swallowing-related cough...
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An Increasing Trend of Eosinophilic Esophagitis in Korea and the Clinical Implication of the Biomarkers to Determine Disease Activity and Treatment Response in Eosinophilic Esophagitis

Kim GH, Park YS, Jung KW, Kim M, Na HK, Ahn JY, Lee JH, Kim DH, Choi KD, Song HJ, Lee GH, Dellon ES, Jung HY

  • KMID: 2460482
  • J Neurogastroenterol Motil.
  • 2019 Oct;25(4):525-533.
  • doi: 10.5056/jnm19066
BACKGROUND/AIMS: The epidemiology and pathogenesis of eosinophilic esophagitis (EoE) remain unclear in Asian countries. We investigated clinicopathological characteristics and diagnostic trends of EoE, and evaluated 3 tissue biomarkers for correlation...
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Role of Esophageal Mean Nocturnal Baseline Impedance and Post-reflux Swallow-induced Peristaltic Wave Index in Discriminating Chinese Patients With Heartburn

Sun YM, Gao Y, Gao F

  • KMID: 2460480
  • J Neurogastroenterol Motil.
  • 2019 Oct;25(4):515-520.
  • doi: 10.5056/jnm19056
BACKGROUND/AIMS: Recently, esophageal mean nocturnal baseline impedance (MNBI) and post-reflux swallow-induced peristaltic wave (PSPW) index have been proposed, which can increase the diagnostic role of multichannel intraluminal impedance and pH...
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High-resolution Manometry Findings During Solid Swallows Correlate With Delayed Reflux Clearance and Acid Exposure Time in Non-erosive Reflux Disease Patients

Ribolsi M, Biasutto D, Giordano A, Balestrieri P, Cicala M

  • KMID: 2433499
  • J Neurogastroenterol Motil.
  • 2019 Jan;25(1):68-74.
  • doi: 10.5056/jnm18054
BACKGROUND/AIMS: The role of esophageal motility in determining gastroesophageal reflux disease (GERD) severity has not been completely evaluated. A few studies have investigated high-resolution manometry (HRM) patterns during solid swallows....
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Prevalence of Eosinophilic Esophagitis in Adult Patients with Upper Gastrointestinal Symptoms in a Locality in Upper Egypt

Fouad M, Fouad YM, Mokareb HA, Mohamed EA, Abdel-Rehim DM

BACKGROUND/AIMS: Eosinophilic esophagitis (EoE) is gaining importance in the diagnosis of upper gastrointestinal (UGI) symptoms. Diagnosis is based on the clinical presentation of esophageal dysfunction and pathological findings in the...
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A Single-center Experience of Esophageal Eosinophilia

Cho KW, Huh CW, Jung DH, Youn YH, Park H

BACKGROUND/AIMS: Esophageal eosinophilia occurs in many conditions, including eosinophilic esophagitis (EoE) and proton pump inhibitor-responsive esophageal eosinophilia (PPI-REE), which have been increasingly recognized in Western countries. There have been only...
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Lower and Upper Gastrointestinal Symptoms Differ Between Individuals With Irritable Bowel Syndrome With Constipation or Chronic Idiopathic Constipation

Shah ED, Almario CV, Spiegel BM, Chey WD

  • KMID: 2413106
  • J Neurogastroenterol Motil.
  • 2018 Apr;24(2):299-306.
  • doi: 10.5056/jnm17112
BACKGROUND/AIMS: We evaluated the distribution of lower and upper gastrointestinal (GI) symptoms among individuals with irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in a nationwide survey. METHODS:...
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Diagnostic Trends and Clinical Characteristics of Eosinophilic Esophagitis: A Korean, Single-center Database Study

Kim GH, Jung KW, Jung HY, Choi KD, Lee J, Park YS, Kim SW, Lee JH, Kim DH, Ahn JY, Song HJ, Lee GH, Kim JH

  • KMID: 2413101
  • J Neurogastroenterol Motil.
  • 2018 Apr;24(2):248-254.
  • doi: 10.5056/jnm17047
BACKGROUND/AIMS: The prevalence of eosinophilic esophagitis (EoE) is reportedly increasing in Western countries. However, its prevalence in Korea remains unknown. We investigated the diagnostic trends and clinical characteristics of EoE...
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Juice Test for Identification of Nonerosive Reflux Disease in Heartburn Patients

Fernandes , De Oliveira M, Callegari-Jacques SM, Gonçalves GVR, Fornari F

  • KMID: 2413099
  • J Neurogastroenterol Motil.
  • 2018 Apr;24(2):233-240.
  • doi: 10.5056/jnm17077
BACKGROUND/AIMS: Evaluation of esophageal clearance by orange juice swallowing could be useful to identify different categories of gastroesophageal reflux disease. We determined whether a juice test at the beginning of...
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Analysis of Relationship between Reflux Symptom Index and Psychiatric Problems

Park IJ, Kang JM, Seo JH, Hwang SH, Youn HY, Jin HJ, Kang HR, Joo YH

BACKGROUND AND OBJECTIVES: This study investigated the relationship between reflux symptom index (RSI) and psychiatric problems such as depression, somatization, and anxiety. SUBJECTS AND METHOD: We prospectively analyzed 231 patients with...
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Prospective Single Arm Study on the Effect of Ilaprazole in Patients with Heartburn but No Reflux Esophagitis

Song IJ, Kim HK, Lee NK, Lee SK

PURPOSE: Patients with gastroesophageal reflux disease without esophagitis show varying responses to proton pump inhibitors (PPIs). The aim of this study was to objectively evaluate the effect of a new...
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Current Trends in the Management of Gastroesophageal Reflux Disease

Sandhu DS, Fass R

Gastroesophageal reflux disease (GERD) characterized by heartburn and/or regurgitation symptoms is one of the most common gastrointestinal disorders managed by gastroenterologists and primary care physicians. There has been an increase...
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Understanding the Rome IV: Esophageal Disorders

Park MI

The Rome IV criteria, published in 2016, encompass upper gastrointestinal lesions of functional esophageal disorders and functional gastroduodenal disorders. Functional esophageal disorders include functional chest pain, functional heartburn, reflux hypersensitivity,...
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Clinical Characteristics of Patients with Untreated Achalasia

Jeon HH, Kim JH, Youn YH, Park H, Conklin JL

  • KMID: 2387828
  • J Neurogastroenterol Motil.
  • 2017 Jul;23(3):378-384.
  • doi: 10.5056/jnm16177
BACKGROUND/AIMS: Patients with untreated achalasia frequently complain of heartburn and regurgitation. The diagnosis of achalasia might be delayed because these symptoms are misinterpreted as gastroesophageal reflux. We aim to evaluate...
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Taste and Smell Disturbances in Patients with Gastroparesis and Gastroesophageal Reflux Disease

Kabadi A, Saadi M, Schey R, Parkman HP

  • KMID: 2387827
  • J Neurogastroenterol Motil.
  • 2017 Jul;23(3):370-377.
  • doi: 10.5056/jnm16132
BACKGROUND/AIMS: Patients with gastroparesis and gastroesophageal reflux disease (GERD) often report decreased enjoyment when eating. Some patients remark that food does not smell or taste the same. To determine if...
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