Korean J Med.  2017 Aug;92(4):354-361. 10.3904/kjm.2017.92.4.354.

Understanding the Rome IV: Esophageal Disorders

• Park MI

• KMID: 2392342
• DOI: http://doi.org/10.3904/kjm.2017.92.4.354

Abstract

The Rome IV criteria, published in 2016, encompass upper gastrointestinal lesions of functional esophageal disorders and functional gastroduodenal disorders. Functional esophageal disorders include functional chest pain, functional heartburn, reflux hypersensitivity, globus, and functional dysphagia. Patients with functional esophageal disorders typically have esophageal symptoms that are not associated with structural, inflammatory, or major esophageal motor disorders. Although the mechanisms of symptom generation in functional esophageal disorders are unclear, visceral hypersensitivity and hypervigilance may play a role. Therefore, treatment options include drugs and modalities that affect peripheral triggering and central perception. Further well-designed studies are needed to identify the mechanisms of symptom generation in, and to develop appropriate therapies for, functional esophageal disorders.

Keyword

Functional chest pain; Functional heartburn; Reflux hypersensitivity; Globus; Functional dysphagia

MeSH Terms

Anxiety
Chest Pain
Deglutition Disorders
Heartburn
Humans
Hypersensitivity
Motor Disorders