Gut Liver.
2023 Nov;17(6):831-842. 10.5009/gnl220373.
Esophageal Reflux Hypersensitivity: A Comprehensive Review
- Affiliations
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- 1Department of Gastroenterology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan
- 2Wingate Institute of Neurogastroenterology, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
- KMID: 2548442
- DOI: http://doi.org/10.5009/gnl220373
Abstract
- Reflux hypersensitivity (RH) is one of the phenotypes of gastroesophageal reflux disease. The latest Rome IV defines RH as a condition with typical reflux symptoms and positive reflux-symptom association despite normal acid exposure. Subsequently, the Lyon consensus proposed detailed cutoff values for the criteria on the basis of experts’ consensus. Rome IV brought a clear-cut perspective into the pathophysiology of gastroesophageal reflux disease and the importance of esophageal hypersensitivity. This perspective can be supported by the fact that other functional gastrointestinal disorders such as irritable bowel syndrome and functional dyspepsia often overlap with RH. Although several possible pathophysiological mechanisms of esophageal hypersensitivity have been identified, there is still unmet medical needs in terms of treatment for this condition. This review summarizes the current knowledge regarding RH.
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