J Menopausal Med.  2014 Dec;20(3):104-110. 10.6118/jmm.2014.20.3.104.

Clinical and Biochemical Profiles according to Homeostasis Model Assessment-insulin Resistance (HOMA-IR) in Korean Women with Polycystic Ovary Syndrome

• Lee DE
• Park SY
• Park SY
• Lee SR
• Chung HW
• Jeong K

• KMID: 2325471
• DOI: http://doi.org/10.6118/jmm.2014.20.3.104

Abstract

OBJECTIVES
The aim of this study was to investigate the clinical and biochemical profiles according to homeostasis model assessment of insulin resistance (HOMA-IR) in Korean polycystic ovary syndrome (PCOS) patients.
METHODS
In 458 PCOS patients diagnosed by the Rotterdam European Society for Human Reproduction and Embryology (ESHRE) criteria, measurements of somatometry, blood test of hormones, glucose metabolic and lipid profiles, and transvaginal or transrectal ultrasonogram were carried out. HOMA-IR was then calculated and compared with the clinical and biochemical profiles related to PCOS. The patients were divided into 4 groups by quartiles of HOMA-IR.
RESULTS
The mean level of HOMA-IR was 2.18 +/- 1.73. Among the four groups separated according to HOMA-IR, body weight, body mass index (BMI), waist-to-hip ratio (WHR), triglyceride (TG), total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, lipid accumulation product (LAP) index, high-sensitivity C-reactive protein (hs-CRP), Apoprotein B, free testosterone, and sex hormone binding globulin (SHBG) were found to be significantly different. TG, LAP index, glucose metabolic profiles, and hs-CRP were positively correlated with HOMA-IR after adjustment for BMI.
CONCLUSION
Our results suggest that the clinical and biochemical profiles which are applicable as cardiovascular risk factors are highly correlated with HOMA-IR in Korean women with PCOS.

Keyword

Cardiovascular diseases; Homeostasis; Insulin resistance; Polycystic ovary syndrome; Risk factors

MeSH Terms

Apoproteins
Body Mass Index
Body Weight
C-Reactive Protein
Cardiovascular Diseases
Cholesterol
Embryology
Female
Glucose
Hematologic Tests
Homeostasis*
Humans
Insulin Resistance
Lipid Accumulation Product
Lipoproteins
Metabolome
Polycystic Ovary Syndrome*
Reproduction
Risk Factors
Sex Hormone-Binding Globulin
Testosterone
Triglycerides
Ultrasonography
Waist-Hip Ratio
Apoproteins
C-Reactive Protein
Cholesterol
Glucose
Lipoproteins
Sex Hormone-Binding Globulin
Testosterone