J Korean Soc Transplant.  2001 Jun;15(1):106-109.

Successful Immunosuppression with Cyclosporine after Renal Transplantation in a Patient with Chronic Renal Failure Due to Postpartum Hemolytic Uremic Syndrome

• Kim JH
• Hwang MH
• Song MS
• Yoon CH
• Kim YM
• Lee KY
• Park SG

Abstract

Hemolytic uremic syndrome is characterized by the symptoms of microangiopathic hemolytic anemia, thrombocytopenia and renal failure. The incidence of hemolytic uremic syndrome associated with pregnancy is 10 to 25 percent. Hemolytic uremic syndrome is treated with adjunctive therapies, such as anti-platelet agents, glucocorticoid and plasma exchange. However, many patients experience a residual impairment in renal function and some of them progress to end-stage renal disease requiring dialysis or renal transplantation. Immunosuppression with cyclosporine has been implicated as a significant risk factor for post- transplant hemolytic uremic syndrome. A number of reports on transplant recipients have recognized cyclosporine-induced hemolytic uremic syndrome as a distinct entity and a potentially serious complication of cyclosporine administration.We report a case of a patient with successful renal transplantation using cyclosporine who had a severe case of post-partum hemolytic uremic syndrome that progressed to end-stage renal disease. After cadaver-donor renal transplantation using cyclosporine, mycophenolate mofetil and prednisolone her graft function at two years is normal with serum creatinine 1.0 mg/dl.

Keyword

Postpartum hemolytic uremic syndrome; Cyclosporine; Renal transplantation

MeSH Terms

Anemia, Hemolytic
Creatinine
Cyclosporine*
Dialysis
Hemolytic-Uremic Syndrome*
Humans
Immunosuppression*
Incidence
Kidney Failure, Chronic*
Kidney Transplantation*
Plasma Exchange
Postpartum Period*
Prednisolone
Pregnancy
Renal Insufficiency
Risk Factors
Thrombocytopenia
Transplantation
Transplants
Creatinine
Cyclosporine
Prednisolone