J Korean Soc Plast Reconstr Surg.
2003 Jul;30(4):483-490.
Effect of Growth Hormone on Early Bony Regeneration in Distraction Osteogenesis
- Affiliations
-
- 1Department of Plastic & Reconstructive Surgery, College of Medicine, Kyungpook National University, Daegu, Korea. bccho@knu.ac.kr
- 2Department of Biochemistry, College of Medicine, Kyungpook National University, Daegu, Korea.
- 3Department of Veterinary Medicine, Kyuungpook National University, Daegu, Korea.
- 4Biomedical Research Center, Korea Institute of Science and Technology, Korea.
Abstract
- The purpose of this project was to study the effect of growth hormone on early bony consolidation in distraction osteogenesis of a dog mandible. Sixteen dogs were used for this study. An external distraction device was applied to the mandibular body and the mandibular distraction was started five days after the operation at a rate of 1 mm per day up to a 10-mm distraction. Dogs in the growth hormone group received a daily subcutaneous injection of 1 IU of recombinant human growth hormone per kilogram of body weight per week. Normal saline was injected in the control group. Bone mineral density was higher in the growth hormone group than the control group in the whole period. Bone mechanical strength was 300% higher in the growth hormone group than that in the control group. However, results were more suggestive than conclusive. Upon histological examination, the formation of a substantial amount of active woven bone was observed throughout the distracted zone in 6 weeks in the growth hormone group. In the control group, new bone was generated from the edge to the center of the distracted zone. But, the most central area of the distracted zone was filled with fibrous tissue in 6 weeks. In conclusion, growth hormone appears to be effective in early bony consolidation in distraction osteogenesis.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Distraction osteogenesis on mandible symphysis widening with a bone-borne type distractor
- Age Related Local Growth Factors Affect Muscle Regeneration in Distraction Osteogenesis
- Case reports of antero-posteior movement with distraction osteogenesis in maxillary anterior segment
- Histological changes and expression of nerve growth factor in the inferior alveolar nerve after distraction osteogenesis
- The effect of oscillating distraction osteogenesis on new bone formation during mandibular distraction period in rabbits
