Soonchunhyang Med Sci.  2015 Dec;21(2):142-145. 10.0000/sms.2015.21.2.142.

Uterine Cervix Metastasis in Lung Adenocarcinoma with Anaplastic Lymphoma Kinase Rearrangement

• Choi S
• Park CK
• Kim SY
• Yoon HK
• Ro SM
• Nam Y

• KMID: 2317776
• DOI: http://doi.org/10.0000/sms.2015.21.2.142

Abstract

The importance of anaplastic lymphoma kinase (ALK) as an oncogene in non-small cell lung cancer (NSCLC) has emerged as a major concern due to a dramatic clinical effect of targeted therapy. As compared with the research for targeted therapy, the study about clinicopathological characteristics for ALK positive NSCLC hasn't been worked enough. Here, we describe a 35-year-old woman diagnosed with stage IVb NSCLC with ALK rearrangement. During evaluating her disease, a metastatic lesion to uterine cervix was found. Although lung cancer metastasis to female genital tract is rare, we also present case series that show a metastasis to the female genital tract in NSCLC with ALK rearrangement. These case series could suggest that ALK positive NSCLC has distinct metastatic pattern.

Keyword

Cervix; Metastasis; Anaplastic lymphoma kinase; Lung neoplasms; Adenocarcinoma of lung; Crizotinib

MeSH Terms

Adenocarcinoma*
Adult
Carcinoma, Non-Small-Cell Lung
Cervix Uteri*
Female
Glycogen Storage Disease Type VI
Humans
Lung Neoplasms
Lung*
Lymphoma*
Neoplasm Metastasis*
Oncogenes
Phosphotransferases*
Phosphotransferases