Soonchunhyang Med Sci.  2012 Jun;18(1):38-42.

Relationship between Serum Leptin Levels and Atherosclerosis in Type 2 Diabetes Patients

• Kong MG
• Yeum SC
• Choo JW
• Park HK

Abstract

OBJECTIVE
Many studies have suggested that leptin is a possible cause of atherosclerosis and is proposed as a cardiovascular risk factor in obese patients. Several studies have shown that serum leptin is associated with pulse wave velocity (PWV) and carotid intima-media thickness (IMT). But the relevance of serum leptin levels for predicting incident cardiovascular disease is less clear. In this study, we investigated the relationship between serum leptin levels and aortic PWV, carotid IMT in type 2 diabetes (T2DM) patients.
METHODS
Patients with end-stage renal disease or advanced atherosclerosis, systemic infection were excluded. A total of 116 patients (60 male/56 female; age, 59+/-14 years) were included. Serum leptin levels, aortic PWV and carotid IMT were measured.
RESULTS
Aortic PWV was significantly associated with age (r=0.28, P<0.005). Carotid IMT was significantly related to age (r=0.46, P<0.001), low density lipoprotein (LDL) cholesterol (r=0.22, P<0.05), lipoprotein (a) (r=0.23, P<0.05) and estimated glomerular filteration rate (r=-0.348, P<0.01). There was no correlation between leptin and aortic PWV or carotid IMT. In multivariate analyses, aortic PWV was associated with age (P=0.007). Carotid IMT was significantly related to age (P<0.001), LDL cholesterol (P=0.01).
CONCLUSION
Serum leptin was not associated with aortic PWV or carotid IMT in T2DM patients.

Keyword

Leptin; Atherosclerosis; Type 2 diabetes mellitus

MeSH Terms

Atherosclerosis
Cardiovascular Diseases
Carotid Intima-Media Thickness
Cholesterol
Cholesterol, LDL
Diabetes Mellitus, Type 2
Humans
Kidney Failure, Chronic
Leptin
Lipoprotein(a)
Lipoproteins
Multivariate Analysis
Pulse Wave Analysis
Risk Factors
Cholesterol
Cholesterol, LDL
Leptin
Lipoprotein(a)
Lipoproteins