Psychiatry Investig.  2015 Jan;12(1):55-60. 10.4306/pi.2015.12.1.55.

The Short-Term Effects of Risperidone-Induced Hyperprolactinemia on Lipid Metabolism in Drug-Naive Children and Adolescents

• Park EJ
• Park YM

• KMID: 2316389
• DOI: http://doi.org/10.4306/pi.2015.12.1.55

Abstract

OBJECTIVE
The present cross-sectional study was designed to assess the risk of elevated prolactin levels and other hormonal or metabolic changes in children and adolescents taking risperidone.
METHODS
Twenty-five children and adolescents [aged 7-18 years, 12.1+/-3.3 years (mean+/-SD); 19 boys and 6 girls] who had been taking risperidone for at least 3 months were enrolled. The following blood parameters were measured: serum levels of prolactin, thyroid hormones, alanine transaminase (ALT), sex hormones, lipids.
RESULTS
The median risperidone dosage was 1.55 mg/day (SD 1.14 mg/day, range 0.25-4.00 mg/day). The prolactin level (33.65+/-16.71 ng/mL, range 5.8-68.3 ng/mL) was higher than normal, and was elevated (> or =15 ng/mL in male, > or =23.3 ng/mL in female) in about 84% of the patients. The dosage of risperidone was positively correlated with serum prolactin level (r=0.767, p<0.001). The TG/HDL ratio was higher in the group with higher prolactin levels (i.e., > or =30 ng/mL), and hence might be a useful marker of insulin resistance.
CONCLUSION
In young patients taking risperidone, a high serum prolactin level may influence lipid metabolism, even when cholesterol levels are within the normal range. Further investigation is needed around this issue. Serum prolactin assessment is recommended for children and adolescents taking risperidone.

Keyword

Risperidone; Hyperprolactinemia; Prolactin; Antipsychotics; Lipid

MeSH Terms

Adolescent*
Alanine Transaminase
Antipsychotic Agents
Child*
Cholesterol
Cross-Sectional Studies
Gonadal Steroid Hormones
Humans
Hyperprolactinemia*
Insulin Resistance
Lipid Metabolism*
Male
Prolactin
Reference Values
Risperidone
Thyroid Hormones
Alanine Transaminase
Antipsychotic Agents
Cholesterol
Gonadal Steroid Hormones
Prolactin
Risperidone
Thyroid Hormones